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Mesenchymal stem cell (MSc) secretome: A possible therapeutic strategy for intensive-care COVID-19 patients
(2020-09-01)
As an emerging global health challenge, COVID-19 requires international knowledge to reach novel possible therapeutic strategies, especially for intensive-care patients. During the early stages of infection, pneumocytes ...
Effect of human mesenchymal stem cell secretome administration on morphine self-administration and relapse in two animal models of opioid dependence
(2022)
The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in ...
Cell-Free Therapies: Novel Approaches for COVID-19
(Frontiers Media, 2020)
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
(2020)
Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
(2020)
Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies
(Facultad de Ciencias de la Salud, 2019)
Previous studies have indicated that mesenchymal stem cells (MSCs) have a fundamental role in the repair and regeneration of damaged tissues. There is strong evidence showing that much of the beneficial effects of these ...
Effect of TGF-b1 stimulation on the secretome of human adipose-derived mesenchymal stromal cells
(Wiley, 2015-08)
Adipose tissue is an attractive source of mesenchymal stromal cells (MSCs) owing to the relative ease of obtaining large volumes with more MSC abundance compared with other sources. Increasing evidence supports the fact ...
Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies
(2019-10-01)
Previous studies have indicated that mesenchymal stem cells (MSCs) have a fundamental role in the repair and regeneration of damaged tissues. There is strong evidence showing that much of the beneficial effects of these ...
La administración sistémica de secretoma obtenido de células madre mesenquimáticas precondicionadas in vitro con deferoxamina, disminuye la atrofia axonal, la apoptosis de las células de Schwann y la pérdida de mielina en nervio ciático junto con estimular la regeneración axonal en el modelo animal de neuropatía diabética BKS DB/DB
(Universidad de Chile, 2020)
En la neuropatía diabética (ND) es una de las principales complicaciones de la diabetes mellitus
(DM) afectando aproximadamente al 60% de los pacientes diabéticos. Se ha propuesto el aumento
en el nivel de especies ...
Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy
(PLoS, 2017)
Diabetic neuropathy (DN) is one of the most frequent and troublesome complications of diabetes mellitus. Evidence from diabetic animal models and diabetic patients suggests that reduced availability of neuroprotective and ...