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Duplo papel da proteína MSH2 no reparo de erros de pareamento no DNA e na resposta ao estresse oxidativo em tripanosomatídeos
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2015-03-09)
Different mechanisms are involved in maintaining genomic stability; among them
is the DNA Mismatch Repair (MMR). Mainly responsible for the recognition of
mismatches and insertion/deletion loops after DNA replication, ...
Estudo do papel das proteínas MSH2 e MSH6 na resposta a danos no DNA em Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2011-02-07)
Trypanosoma cruzi, etiologic agent of Chagas disease, presents a highly
heterogeneous population structure, characterized by the occurrence of different strains
with different biochemical and morphological characteristics. ...
The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana
(Elsevier Science, 2020-03)
The mismatch repair (MMR) pathway promotes genome stability by controlling the fidelity of replication and recombination. The first step of the pathway involves recognition of the mismatch by heterodimers composed of MutS ...
Light modulates the melanophore response to alpha-MSH in Xenopus laevis: An analysis of the signal transduction crosstalk mechanisms involved
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Melanin granule (melanosome) dispersion within Xenopus laevis melanophores is evoked either by light or alpha-MSH. We have previously demonstrated that the initial biochemical steps of light and alpha-MSH signaling are ...
DNA mismatch repair gene methylation in gastric cancer in individuals from northern Brazil
(INST HISTOL EMBRIOL-CONICET, 2008)
Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation status of MLH1, MSH2, MSH6 and PMS2 in 20 ...
High-level production of MSH2 from Arabidopsis thaliana: a DNA mismatch repair system key subunit
(Humana Press, 2011-02)
Biochemical and immunological information concerning DNA mismatch repair proteins from higher plants is currently limited, probably due to their low abundance in vivo. An initial analysis of AtMSH2 gene expression by ...
MSH2 e o reparo de erros de pareamento em tripanossomatídeos: análises in vitro e in vivo e envolvimento na resposta a estresse oxidativo
(Universidade Federal de Minas GeraisUFMG, 2008-02-14)
Recent studies carried out by our group have demonstrated that the species T. cruzi can be divided into three distinct haplogroups, named A, B and C. This division was based upon extensive analyses carried out in several ...
Peptide-lipid interaction monitored by spin labeled biologically active melanocortin peptides
(Elsevier B.V., 2005-10-01)
The present work comparatively analyzes the interaction of alpha-MSH and its more potent and long-acting analog [Nle(4), D-Phe(7)]alpha-MSH (NDP-MSH) with lipid bilayers. the peptides were spin labeled with Toac ...
Effect of NDP-a-MSH on PPAR-c and –b Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia
(Public Library Science, 2013-02-26)
Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. ...