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CIITA B-cell specific promoter suppression in MHC class II-silenced cell hybrids
(Springer-Verlag, 1998)
In this study, various sets of somatic cell hybrids,
generated by the fusion of epithelial cell lines
with B-lymphoblastoid cell lines, were analyzed for the
expression of major histocompatibility complex (MHC)
class ...
Incomplete silencing of full mutation alleles in males with fragile X syndrome is associated with autistic features
(BioMed Central, 2019)
Background: Fragile X syndrome (FXS) is a common monogenic cause of intellectual disability with autism features. While it is caused by loss of the FMR1 product (FMRP), mosaicism for active and inactive FMR1 alleles, ...
Staufen: From Embryo Polarity to Cellular Stress and Neurodegeneration
(Frontiers In Bioscience, 2012-01)
Staufen is a double-stranded RNA-binding protein that forms RNA granules by RNA-dependent and -independent interactions. Staufen was initially described in Drosophila as a key molecule for targeting maternal mRNAs. In ...
Synaptic Activity Regulated mRNA-Silencing Foci for the Fine Tuning of Local Protein Synthesis at the Synapse
(Landes Bioscience, 2012)
The regulated synthesis of specific proteins at the synapse is important for neuron plasticity, and several localized mRNAs are translated upon specific stimulus. Repression of mRNA translation is linked to the formation ...
Smaug variants in neural and non-neuronal cells
(Taylor & Francis, 2016-02)
Mammalian Smaug1/Samd4a is an mRNA regulator involved in synapse plasticity and additional non-neuronal functions. Here we analyzed the expression of Smaug1/Samd4a variants and Smaug2/Samd4b in primary hippocampal neurons ...
PSA secretion and cell proliferation are affected by NCoR1 silencing in prostate cancer cells
(HCPA/FAMED/UFRGS, 2020)
FMR1 mRNA from full mutation alleles is associated with ABC-C-FX scores in males with fragile X syndrome
(Nature, 2020)
Fragile X syndrome (FXS) is caused by a hypermethylated full mutation (FM) expansion with >= 200 CGG repeats, and a decrease in FMR1 mRNA and its protein. However, incomplete silencing from FM alleles has been associated ...
Preliminary analysis of miRNA pathway in Schistosoma mansoni
(ELSEVIER IRELAND LTD, 2009)
RNA silencing refers to a series of nuclear and cytoplasmatic processes involved in the post-transcriptional regulation of gene expression or post-transcriptional gene silencing (PTGS), either by sequence-specific mRNA ...
Genetic transformation of Citrus sinensis with Citrus tristeza virus (CTV) derived sequences and reaction of transgenic lines to CTV infection
(SPRINGERDORDRECHT, 2013-08-02)
Transgenic Citrus sinensis (L.) Osb. plants, cvs. Valencia and Hamlin, expressing Citrus tristeza virus (CTV) derived sequences were obtained by genetic transformation. The gene constructs were pCTV-CP containing the 25 ...