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Glutamatergic Neurotransmission Controls the Functional Lateralization of the mPFC in the Modulation of Anxiety Induced by Social Defeat Stress in Male Mice
(2021-08-23)
The rodent medial prefrontal cortex (mPFC) is anatomically divided into cingulate (Cg1), prelimbic (PrL), and infralimbic (IL) subareas. The left and right mPFC (L and RmPFC) process emotional responses induced by ...
5-HT2a receptor in mPFC controls context-guided reconsolidation of long- term object memory in perirhinal cortex
(Sociedad Argentina de Investigación en Neurociencias, 2017)
The object recognition memory retrieval is a complex process that required the interaction of multiples structures. It has been proposed that mPFC interacts with the hippocampus (HIP) during contextual-guided versions of ...
Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats
(2019-08)
Schizophrenia (SZ) is associated with changes in the structure and function of several brain areas. Several findings suggest that these impairments are related to a dysfunction in g-aminobutyric acid (GABA) neurotransmission ...
Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)
(Elsevier B.V., 2014-07-01)
The medial prefrontal cortex (mPFC) and the neuropeptide corticotropin-releasing factor (CRF) have recently been receiving more attention from those interested in the neurobiology of anxiety. Here, we investigated the CRF ...
Functional lateralization of the medial prefrontal cortex in the modulation of anxiety in mice: Left or right?
(2016-09-01)
It has been suggested that the left medial prefrontal cortex (LmPFC) has an inhibitory role in controlling the right mPFC (RmPFC), thereby reducing the deleterious effects of stressors on emotional states. Here, we ...
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3
(Frontiers Media SA, 2018)
TRPM4 is a Ca2+-activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained activity in several brain regions, however, the cellular and ...
The medial forebrain bundle mediates cardiovascular responses to electrical stimulation of the medial prefrontal cortex
(ELSEVIER SCIENCE BV, 2009)
The medial prefrontal cortex (MPFC) is involved in cardiovascular control. MPFC electrical stimulation has been reported to cause depressor and bradycardic responses in anesthetized rats. Although the pathway involved is ...
5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex
(eLife Sciences Publications Ltd, 2018-05)
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is ...
Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST
(2020-04-01)
Nitric oxide (NO) release in the right medial prefrontal cortex (RmPFC) produces anxiogenesis. In the bed nucleus of the stria terminalis (BNST), a region that receives neuronal projections from the mPFC, NO provokes ...
Inhibition of the left medial prefrontal cortex (mPFC) prolongs the social defeat-induced anxiogenesis in mice: Attenuation by NMDA receptor blockade in the right mPFC
(2020-01-27)
Chemical inhibition and nitrergic stimulation of the left and right medial prefrontal cortex (L and RmPFC), respectively, provoke anxiety in mice. Moreover, LmPFC inhibition immediately followed by a single social defeat ...