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Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
(Wiley Blackwell Publishing, Inc, 2018-04)
Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP is not licenced for use in dairy animals due to the prolonged elimination of its metabolite monepantel sulphone ...
Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: Pharmacokinetic support to its excellent nematodicidal activity
(Elsevier Science, 2014-03)
The amino-acetonitrile derivatives (AADs) are a new class of anthelmintic molecules active against a wide range of sheep gastrointestinal (GI) nematodes including those that are resistant to other anthelmintic families. ...
Hepatic biotransformation pathways and ruminal metabolic stability of the novel anthelmintic monepantel in sheep and cattle
(Wiley Blackwell Publishing, Inc, 2016-02)
Monepantel (MNP) is a new amino-acetonitrile derivative anthelmintic drug used for the treatment of gastrointestinal (GI) nematodes in sheep. The present work investigated the main enzymatic pathways involved in the hepatic ...
Further insights into monepantel pharmacology to optimise its anthelmintic performance in cattle
(World Association for the Advancement of Veterinary Parasitology, 2021)
The work described here complements previous findings on monepantel (MNP) pharmacological behaviour in cattle. MNP was given alone or co-administered with macrocyclic lactones or benzimidazoles to calves naturally infected ...
Monepantel pharmaco-therapeutic evaluation in cattle: Pattern of efficacy against multidrug resistant nematodes
(Elsevier, 2021-04)
The goal of the current work was to perform an integrated evaluation of monepantel (MNP) pharmacokinetics (PK) and pharmacodynamics, measured as anthelmintic efficacy, after its oral administration to calves naturally ...