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Investigação da ocorrência de eventos epigenéticos em Haemonchus contortus e sua relação com a resistência ao anti-helmíntico monepantel
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2019-02-27)
Parasitism by gastrointestinal nematodes, mainly by Haemonchus contortus, is the major obstacle to sheep production. Anthelmintic treatment is the main method used by farmers to control worms. However, parasites acquire ...
Pharmacokinetic assessment of the monepantel plus oxfendazole combined administration in dairy cows
(Wiley Blackwell Publishing, Inc, 2018-04)
Monepantel (MNP) is a novel anthelmintic compound launched into the veterinary pharmaceutical market. MNP is not licenced for use in dairy animals due to the prolonged elimination of its metabolite monepantel sulphone ...
In vivo selection for Haemonchus contortus resistance to monepantel
(2020-01-01)
Gastrointestinal nematodes significantly affect the ovine industry, and Haemonchus contortus is considered the most pathogenic parasite in tropical regions. This situation is aggravated when the main strategy to control ...
Development of Haemonchus contortus resistance in sheep under suppressive or targeted selective treatment with monepantel
(2017-11-15)
This study examined the development of resistance to anthelmintics in Haemonchus contortus in lambs under suppressive or selective treatment regimens that included monepantel. Twenty Ile de France and 20 Santa Ines lambs ...
Haemonchus contortus resistance to monepantel in sheep: Fecal egg count reduction tests and randomized controlled trials
(2017-01-01)
Worm infections are a major cause of economic losses in sheep farming, and their control depends essentially on anthelmintic drugs. After decades without the discovery of new drug types, a new class of anthelmintics, called ...
Estudo de resistência anti-helmíntica ao monepantel em propriedades de ovinos de uma microrregião em torno de Jaboticabal-SP
(Universidade Estadual Paulista (Unesp), 2016-01-29)
O monepantel, anti-helmíntico de uma nova classe, foi desenvolvido e colocado no mercado recentemente, como solução para criações com helmintos de ovinos multirresistentes. Após pouco tempo de utilização, foram relatados ...
Hepatic biotransformation pathways and ruminal metabolic stability of the novel anthelmintic monepantel in sheep and cattle
(Wiley Blackwell Publishing, Inc, 2016-02)
Monepantel (MNP) is a new amino-acetonitrile derivative anthelmintic drug used for the treatment of gastrointestinal (GI) nematodes in sheep. The present work investigated the main enzymatic pathways involved in the hepatic ...