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Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis
(Expert Reviews, 2008-07-01)
This review discusses some of the impacts that biotechnology, genomics and nanotechnology convergence should have on future cancer management, in particular, the development of innovative diagnostic and therapeutic approaches ...
Hypertension and exercise: A search for mechanisms
(2018-08-01)
HCN Channels: New therapeutic targets for pain treatment
(MDPI AG, 2018)
Urotensin II: Molecular mechanisms of biological activity
(Bentham Science Publishers B.V., 2018)
Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches
(Springer New York LLC, 2016)
Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer’s disease pathology
(Taylor and Francis Ltd, 2017)
Deep Learning to Therapeutically Target Unreported Complexes
(Elsevier Science London, 2019-05-21)
The disruption of large protein–protein (PP) interfaces remains a challenge in targeted therapy. Designing drugs that compete with binding partners is daunting, especially when the structure of the protein complex is ...