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MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1
(American Association for Cancer Research, 2010-04-01)
Leukemias with 11q23 translocations involving the Mixed Lineage Leukemia (MLL) gene exhibit unique clinical and biological features and have a poor prognosis. In a screen for molecular markers of MLL rearrangement, we ...
MLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals
(Sociedade Brasileira de Genética, 2009)
Chromosomal translocations are characteristic of hematopoietic neoplasias and can lead to unregulated oncogene expression or the fusion of genes to yield novel functions. In recent years, different lymphoma/leukemia-associated ...
Preferential induction of MLL (Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide
(Sociedade Brasileira de Genética, 2009)
Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide ...
Discordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia
(1996)
We report the different presentation features and clinical outcome between two identical infant twins with acute lymphoblastic leukaemia with a shared clonal disease and MLL gene rearrangement. One twin relapsed and died, ...
Daño genético persistente inducido por venenos de topoisomerasa II en fibroblastos humanos normales: generación de inestabilidad cromosómicaPersistent genetic damage induced by topoisomerase II poisons in normal human fibroblasts: generation of chromoso me instability
(Sociedad Argentina de Genética, 2016-12)
Topoisomerase II (Top2) poisons idarubicin (IDA) and etoposide (ETO) are anticancer drugs that target Top2 stabilizing DNA-enzymecomplexes and generating double-strand breaks (DSB). These DNA lesions are dangerous because ...
Cytogenetic and molecular analysis of MLL rearrangements in acute lymphoblastic leukaemia survivors
(OXFORD UNIV PRESS, 2009)
The successful treatment of paediatric malignancies by multimodal therapy has improved outcomes for children with cancer, especially those with acute lymphoblastic leukaemia (ALL). Second malignant neoplasms, however, ...
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype
(ELSEVIER SCIENCE INC, 2010)
We report a case of acute monoblastic leukemia showing a jumping translocation with the MLL gene in a 17-year-old male. Classic cytogenetic and spectral karyotyping revealed a complex karyotype, and fluorescence in situ ...
Significado clínico y frecuencia de la alteración genético/molecular 11q23/MLL en lactantes con leucemia aguda en Chile
(Sociedad Médica de Santiago, 2001)
Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District
(Funpec-editoraRibeirao PretoBrasil, 2009)