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Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells
(Libertas Academica, 2013-01)
We have previously shown that the antiprogestin and antiglucocorticoid mifepristone inhibits the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused by mifepristone is limited to ...
FOLLICLE-STIMULATING HORMONE-GRANULOSA CELL AXIS INVOLVEMENT IN THE ANTIFOLLICULOTROPHIC EFFECT OF LOW-DOSE MIFEPRISTONE (RU486)
(OXFORD UNIV PRESS UNITED KINGDOM, 1995)
This study was designed to assess the involvement of follicle stimulating hormone (FSH)-granulosa and luteinizing hormone (LH)-theca axes in the antifolliculotrophic effect of mifepristone. Plasma gonadotrophins, including ...
Pituitary changes involved in prolactin secretion induced by mifepristone and naloxone during late pregnancy
(Karger, 2009-10)
The antiprogesterone mifepristone facilitates prolactin release, an effect enhanced by administration of the opioid antagonist naloxone. The present study explores ultrastructural changes in lactotropes after mifepristone ...
Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells
(Elsevier, 2018)
Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...
Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy
(BioMed Central, 2012-05)
Background: Advanced ovarian cancer is treated with cytoreductive surgery and combination platinum- and taxane-based chemotherapy. Although most patients have acute clinical response to this strategy, the disease ultimately ...
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors
(Elsevier, 2016-08)
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of ...
Role for mifepristone in breast cancer
(Nova Science Publisher's, 2014)
Mifepristone (MFP) is an antiprogestin that has shown some beneficial effects in breast cancer clinical trials. Interestingly, progestins such as medroxyprogesterone acetate (MPA) have also been used as second or third ...
Mifepristone, a blocker of glucocorticoid receptors, promotes photoreceptor death
(Association for Research in Vision and Ophthalmology, 2013-01)
PURPOSE: Glucocorticoids are best known by their protective effect on retinal photoreceptor damage. However, they could also be involved in photoreceptor homeostasis under basal, nonstressful conditions. Therefore, we aimed ...
Role of Estradiol in the Regulation of Prolactin Secretion During Late Pregnancy
(Springer/Plenum Publishers, 2016-12)
Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action ...