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Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies
(Wiley Blackwell Publishing, Inc, 2022-01)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting toxicity that affects 30%-40% of patients undergoing cancer treatment. Although multiple mechanisms of chemotherapy-induced neurotoxicity have ...
Microtubule configuration and its relationship to sperm morphology in mammalian spermiogenesis
(2008)
The acrosome is a secretory vesicle located in the mammalian sperm head. Its main function is to transport hydrolytic enzymes. These enzymes will dissolve the zona pellucid, assisting the sperm in fertilizing the egg. The ...
Investigação de moléculas híbridas para o tratamento anticâncer
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosBiotecnologia - Biotec, 2022-07-06)
Cancer is the attribution given to the uncontrolled growth and proliferation of abnormal cells capable of invading and destroying the adjacent tissue. According to the World Health Organization (WHO), the global growth in ...
Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues
(Public Library of Science, 2017)
Interactome Analysis of Microtubule-targeting Agents Reveals Cytotoxicity Bases in Normal Cells
(2017)
Cancer causes millions of deaths annually and microtubule-targeting agents (MTAs) are the most commonly-used anti-cancer drugs. However, the high toxicity of MTAs on normal cells raises great concern. Due to the non-selectivity ...
Microtúbulos y terapia neural: propuesta de una investigación promisoria
(Universidad Militar Nueva Granada, 2011)
Microtúbulos y terapia neural: propuesta de una investigación promisoria
(Universidad Militar Nueva Granada, 2011)
Topological properties and in vitro identification of essential nodes of the Paclitaxel and Vincristine interactomes in PC-3 cells
(2019)
Background: Microtubule-targeting agents (MTAs) disrupt microtubule dynamics, thereby inducing apoptosis via mitochondrial pathway activation through the modulation in the expression of the Bcl-2 family. Methods: To describe ...
Aspectos gerais sobre os principais antineoplásicos utilizados na clínica veterinária de cães e gatos: revisão de literatura
(São Paulo, 2009)
Com o aprimoramento das técnicas de investigação na medicina veterinária, as neoplasias em cães e gatos são cada vez mais diagnosticadas e representam um amplo campo de atuação do médico veterinário como oncologista. ...
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
(2017-03-30)
A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and ...