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Fragment-Based QSAR and Molecular Modeling Studies on a Series of Discodermolide Analogs as Microtubule-Stabilizing Anticancer Agents
(WILEY-V C H VERLAG GMBH, 2009)
Inhibition of microtubule function is an attractive rational approach to anticancer therapy. Although taxanes are the most prominent among the microtubule-stabilizers, their clinical toxicity, poor pharmacokinetic properties, ...
Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin
(Springer New York LLC, 2016)
© 2015, Springer Science+Business Media New York.In this study, we investigated the role of adducts formation between aminochrome and tubulin and its interference in microtubules assembly and stability in aminochrome-induced ...
Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex
(American Society for Biochemistry and Molecular Biology, 2004-10-20)
Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known. ...
Synthesis of the C11-C23 Fragment of the Potent Antitumor Agent Dictyostatin
(Wiley-blackwellMaldenEUA, 2009)
Docking, synthesis and antiproliferative activity of N-acylhydrazone derivatives designed as combretastatin A4 analogues
(Public Library of Science, 2017)
Pixuna virus modifies host cell cytoskeleton to secure infection
(Nature Publishing Group, copyright 2011-, 2017-07-18)
Pixuna virus (PIXV) is an enzootic member of the Venezuelan Equine Encephalitis Virus complex and belongs to the New World cluster of alphaviruses. Herein we explore the role of the cellular cytoskeleton during PIXV ...
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
(2017-03-30)
A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and ...