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Mechanisms underlying the inhibition of the cytochrome P450 system by copper ions
(WILEY, 2009)
Copper toxicity has been associated to the capacity of free copper ions to catalyze the production of superoxide anion and hydroxyl radical, reactive species that modify the structure and/or function of biomolecules. In ...
Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism
(ELSEVIER IRELAND LTD, 2010)
Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
Glucuronidation of apomorphine
(Elsevier, 2000-08-25)
Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, ...
Route of metabolization and detoxication of paralytic shellfish toxins in humans
(ELSEVIER, 2010)
Paralytic shellfish toxins (PST) are a collection of over 26 structurally related imidazoline
guanidinium derivatives produced by marine dinoflagellates and freshwater cyanobacteria.
Glucuronidation of drugs by ...
Atividade da enzima de biotransformação uridina difosfato glicuronosiltransferase (UGT) em Chelonia mydas (Linnaeus, 1758)
(2020)
Uma série de contaminantes químicos pode ser liberada no ambiente associada às atividades humanas. Alguns contaminantes podem causar efeitos tóxicos nos organismos expostos, como as tartarugas-verdes (Chelonia mydas). Essa ...
Estudio de genes candidatos sobre la efectividad y seguridad de la medicación anticonvulsiva en un grupo de pacientes colombianos afectados de epilepsia
(Departamento de FarmaciaUniversidad Nacional de Colombia - Sede Bogotá, 2019-03-13)
Objectives: to explore possible genetic determinants of response to anticonvulsant treatment in a group of Colombian epileptic patients.
Design: prospective cohort analytical observational study. We included 77 adult ...
Reacciones de reducción, oxidación y conjugación del aflatoxicol y la aflatoxina B1 in vitro a partir de extractos de hígado provenientes de cuatro especies de aves de importancia comercial
(Bogotá - Ciencias - Doctorado en BiotecnologíaUniversidad Nacional de Colombia - Sede Bogotá, 2020-09-09)
Enzymatic parameters of in vitro metabolism of aflatoxin B1 (AFB1) in chicken, quail, turkey and duck are related to resistance to AFB1 toxic effects. Duck, a highly sensitive species, produce the higher ammount of ...
Importancia de los disruptores endocrinos en la alimentación bovina
(Universidad de los Llanos, 2013-06-30)
En este artículo de revisión se describen las características químicas de los disruptores endocrinos que pueden contaminar los productos utilizados en la alimentación bovina, así mismo su disponibilidad ambiental y los ...