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Aminochrome induces microglia and astrocyte activation
(Elsevier, 2017)
Aminochrome has been suggested as a more physiological preclinical model capable of inducing five of the six mechanisms of Parkinson's Disease (PD). Until now, there is no evidence that aminochrome induces glial activation ...
Spinal cord injury impairs neurogenesis and induces glial reactivity in the hippocampus
(Springer, 2017-03)
The incorporation of newborn neurons with increased synaptic remodeling and activity-dependent plasticity in the dentate gyrus enhances hippocampal-dependent learning performances. Astrocytes and microglial cells are ...
Progesterone attenuates astro and microgliosis and enhances oligodendrocyte differentittion following spinal cord injury
(Elsevier Inc, 2011-09)
Reactive gliosis, demyelination and proliferation of NG2+ oligodendrocyte precursor cells (OPC) are common responses to spinal cord injury (SCI). We previously reported that short-term progesterone treatment stimulates OPC ...
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus
(Academic Press Inc Elsevier Science, 2019-01)
The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation ...
Avaliação dos efeitos de um inibidor da calcineurina em modelos experimentais da doença de Alzheimer
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE FARMACOLOGIAPrograma de Pós-Graduação em Ciências Biológicas - Fisiologia e FarmacologiaUFMG, 2020-06-30)
Alzheimer’s disease (AD) is the main cause of dementia worldwide. Thus, a better comprehension of its physiopathology and the search for new therapeutic targets are necessary. In this sense, the calcineurin (CN), a protein ...
Colony-stimulating factor-1 receptor inhibition attenuates microgliosis and myelin loss but exacerbates neurodegeneration in the chronic cuprizone model
(Wiley Blackwell Publishing, Inc, 2021-12)
Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive ...
The Progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in Wobbler Mouse motoneuron degeneration
(Elsevier, 2015-11-12)
Wobbler mutant mice suffer from progressive motoneuron degeneration and glial cell reactivity in the spinal cord. To prevent development of these abnormalities, we employed Nestorone, a high-affinity progesterone receptor ...
Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy
(Federation of American Societies for Experimental Biology, 2012-10)
Microglial cells are phagocytes in the central nervous system (CNS) and become activated in pathological conditions, resulting in microgliosis, manifested by increased cell numbers and inflammation in the affected regions. ...