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NetTepi: an integrated method for the prediction of T-cell epitopes
(Springer Verlag Berlín, 2014-08)
Multiple factors determine the ability of a peptide to elicit a cytotoxic T cell lymphocyte response. Binding to a major histocompatibility complex class I (MHC-I) molecule is one of the most essential factors, as no peptide ...
Improved pan-specific MHC class I peptide binding predictions using a novel representation of the MHC binding cleft environment
(Wiley, 2014-02)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico methods have been developed to ...
Identification of the cognate peptide-MHC target of T cell receptors using molecular modeling and force field scoring
(Pergamon-Elsevier Science Ltd, 2018-02)
Interactions of T cell receptors (TCR) to peptides in complex with MHC (p:MHC) are key features that mediate cellular immune responses. While MHC binding is required for a peptide to be presented to T cells, not all MHC ...
Improved methods for predicting peptide binding affinity to MHC class II molecules
(Wiley Blackwell Publishing, Inc, 2018-07)
Major histocompatibility complex class II (MHC-II) molecules are expressed on the surface of professional antigen-presenting cells where they display peptides to T helper cells, which orchestrate the onset and outcome of ...
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification
(Springer, 2015-09)
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound ...
NetMHCstab – predicting stability of peptide–MHC-I complexes; impacts for cytotoxic T lymphocyte epitope discovery
(Wiley, 2014-01)
Major histocompatibility complex class I (MHC-I) molecules play an essential role in the cellular immune response, presenting peptides to cytotoxic T lymphocytes (CTLs) allowing the immune system to scrutinize ongoing ...
Design of a predicted MHC restricted short peptide immunodiagnostic and vaccine candidate for Fowl adenovirus C in chicken infection
(Biomedical Informatics, 2015)
Fowl adenoviruses (FAdVs) are the ethiologic agents of multiple pathologies in chicken. There are five different species of FAdVs grouped as FAdV-A, FAdV-B, FAdV-C, FAdV-D, and FAdV-E. It is of interest to develop ...
Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment
(Wiley, 2014)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico Methods: have been developed to ...
Immunoinformatics: Predicting Peptide–MHC Binding
(Annual Review, 2020-07)
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation ...
Gapped sequence alignment using artificial neural networks: Application to the MHC class I system
(Oxford University Press, 2016-02-15)
Motivation: Many biological processes are guided by receptor interactions with linear ligands of variable length. One such receptor is the MHC class I molecule. The length preferences vary depending on the MHC allele, but ...