Astrocytes play a key role by providing antioxidant support to nearby neurons under oxidative stress. We have previously demonstrated that in vitro astroglial subtype 3 metabotropic glutamate receptor (mGlu3R) is ...

Subtype 3 metabotropic glutamate receptors (mGlu3R) promote several neuroprotective effects, especially in glial cells. We have previously demonstrated that mGlu3R activation in astrocytes promotes the non-amyloidogenic ...

Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation ...

The mechanics of β-amyloid (Aβ) clearance by astrocytes has not been univocally described, with different mediators appearing to contribute to this process under different conditions. Our laboratory has demonstrated ...

Early models for the etiology of schizophrenia focused on dopamine neurotransmission because of the powerful anti-psychotic action of dopamine antagonists. Nevertheless, recent evidence increasingly supports a primarily ...

The mesocorticolimbic circuit projects to the prefrontal cortex, hippocampus, amygdala, and nucleus accumbens, among others, and it originates in the dopaminergic neurons of the ventral tegmental area (VTA). The VTA receives ...

Astrocytes are now fully endorsed as key players in CNS functionality and plasticity. We recently showed that metabotropic glutamate receptor 3 (mGlu3R) activation by LY379268 promotes non-amyloidogenic cleavage of amyloid ...

Obesity, as well as its comorbidities, represents a serious global public health problem. In obese patients, the adipose tissue presents characteristics of a low-grade chronic inflammatory state, which can increase the ...

Data from world health organization and Brazil health ministry shows a worldwide tendency for increased obesity and overweight prevalence. Obesity is a risk factor for several diseases including hypertension, diabetes, ...