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Chronic methionine load-induced hyperhomocysteinemia impairs the relaxation induced by bradykinin in the isolated rat carotid
(SPRINGER, 2009)
This study investigates the effects of chronic methionine intake on bradykinin (BK)-relaxation. Vascular reactivity experiments were performed on carotid rings from male Wistar rats. Treatment with methionine (0.1, 1 or 2 ...
Functional characterization of the Aspergillus nidulans methionine sulfoxide reductases (msrA and msrB)
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009)
Proteins are subject to modification by reactive oxygen species (ROS), and oxidation of specific amino acid residues can impair their biological function, leading to an alteration in cellular homeostasis. Sulfur-containing ...
On the functionality of a methionine sulfoxide reductase B from Trypanosoma cruzi
(Elsevier Science Inc, 2020-07)
BackgroundMethionine is an amino acid susceptible to be oxidized to give a racemic mixture of R and S forms of methionine sulfoxide (MetSO). This posttranslational modification has been reported to occur in vivo under ...
Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei
(Elsevier Science Inc, 2017-11)
To combat the deleterious effects that oxidation of the sulfur atom in methionine to sulfoxide may bring, aerobic cells express repair pathways involving methionine sulfoxide reductases (MSRs) to reverse the above reaction. ...
Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
(Frontiers Media, 2020-11)
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop ...
The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats
(ELSEVIER SCIENCE BV, 2011)
Methionine is a component of one-carbon metabolism and a precursor of S-adenosylmethionine (SAM), the methyl donor for DNA methylation. When methionine intake is high, an increase of S-adenosylmethionine (SAM) is expected. ...
Functional characterization of methionine sulfoxide reductase A from Trypanosoma spp.
(Elsevier Science Inc, 2011-01)
Methionine is an amino acid susceptible to being oxidized to methionine sulfoxide (MetSO). The reduction of MetSO to methionine is catalyzed by methionine sulfoxide reductase (MSR), an enzyme present in almost all organisms. ...
Type I photosensitized oxidation of methionine
(Wiley Blackwell Publishing, Inc, 2021-01)
Methionine (Met) is an essential sulfur-containing amino acid, sensitive to oxidation. The oxidation of Met can occur by numerous pathways, including enzymatic modifications and oxidative stress, being able to cause relevant ...
Oxidative stress in mouse liver caused by dietary amino acid deprivation : protective effect of methionine
(Springer, 2010-06)
The aim of this work was to evaluate the effects of a diet depleted of amino acids (protein-free diet, or PFD), as well as the supplementation with methionine (PFD+Met), on the antioxidant status of the female mouse liver. ...
Adsorption behaviour of cadmium on L-methionine immobilized on controlled pore glass
(Elsevier Science, 2009-03)
The adsorption behaviour of Cd onto the relative non-polar L-methionine was studied. To this end, L-met was immobilized on controlled pore glass (CPG), incorporated in a microcolumn and inserted in a flow injection system ...