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Determinants of anti-cancer effect of mitochondrial electron transport chain inhibitors: Bioenergetic profile and metabolic flexibility of cancer cells
(Bentham Science Publishers B.V., 2016)
© 2016 Bentham Science Publishers. Recent evidence highlights that energy requirements of cancer cells vary greatly from normal cells and they exhibit different metabolic phenotypes with variable participation of both ...
Functional magnetic resonance imaging response as an early biomarker of cognitive decline in elderly patients with metabolic syndrome
(Elsevier B.V., 2017-11-01)
Objectives: We assessed whether potential changes in brain activation patterns of elderly individuals with metabolic syndrome (MetS) who were cognitively healthy (without mild cognitive impairment or dementia) were associated ...
IMPAIRED SULFATED GLYCOSAMINOGLYCAN METABOLISM IN A PATIENT WITH GM-2 GANGLIOSIDOSIS (TAY-SACHS DISEASE)
(Kluwer Academic Publ, 1990-01-01)
IMPAIRED SULFATED GLYCOSAMINOGLYCAN METABOLISM IN A PATIENT WITH GM-2 GANGLIOSIDOSIS (TAY-SACHS DISEASE)
(Kluwer Academic Publ, 1990-01-01)
Metabolic flexibility and insulin resistance
(AMER PHYSIOLOGICAL SOC, 2008-11)
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the ...
Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes
(2019-09-01)
This study examined particularly relevant redox pathways such as glycolysis, pentose phosphate pathway (PPP), metHb reductase and nucleotide metabolism, in order to better address how sickle cells deal with redox metabolism ...
Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus
(2018)
There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. ...
Glucose metabolism and AD: evidence for a potential diabetes type 3
(BMC, 2022)
Background Alzheimer's disease is the most prevalent cause of dementia in the elderly. Neuronal death and synaptic dysfunctions are considered the main hallmarks of this disease. The latter could be directly associated to ...
Alterations in Cytosolic and Mitochondrial [U-C-13] Glucose Metabolism in a Chronic Epilepsy Mouse Model
(Soc Neuroscience, 2017)
Temporal lobe epilepsy is a common form of adult epilepsy and shows high resistance to treatment. Increasing evidence has suggested that metabolic dysfunction contributes to the development of seizures, with previous studies ...