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Expressão dos transportadores de monocarboxilatos de equinos e cães
(Universidade Estadual Paulista (UNESP), 2017-11-13)
O principal mecanismo de transporte dos íons lactato e H+ em equinos e cães é o complexo transportador formado pelos transportadores de monocarboxilatos, isoformas 1 (MCT1) e 4 (MCT4) juntamente com a proteína auxiliar ...
Classificação dos solos e rochas sedimentares da região de Santa Maria/RS segundo a metodologia MCT
(Universidade Federal de Santa MariaBrasilEngenharia CivilUFSMPrograma de Pós-Graduação em Engenharia CivilCentro de Tecnologia, 2016-12-16)
This research aimed to classify soils from the region of Santa Maria, in the state of Rio
Grande do Sul, according to the MCT Methodology, seeking to know the peculiarities
of the tropical soils of the region. The ...
Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
(SPRINGER, 2008)
Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important ...
Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44
(HINDAWI PUBLISHING CORPORATION, 2010)
Monocarboxylate transporters (MCTs) are important cellular pH regulators in cancer cells; however, the value of MCT expression in cancer is still poorly understood. In the present study, we analysed MCT1, MCT2, and MCT4 ...
Characterization of monocarboxylate transporters (MCTs) expression in soft tissue sarcomas: distinct prognostic impact of MCT1 sub-cellular localization
(Biomed Central Ltd., 2014-05-09)
Background: Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer a poor outcome to half of the patients. As other solid tumors, STSs exhibit high glucose consumption ...
Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations
(2009)
Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3′,5-triiodothyronine (T3). Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and ...
Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer
(Oncotarget, 2015-08-28)
Monocarboxylate Transporter 2 (MCT2) is a major pyruvate transporter encoded by the SLC16A7 gene. Recent studies pointed to a consistent overexpression of MCT2 in prostate cancer (PCa) suggesting MCT2 as a putative biomarker ...
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)
(SPRINGER/PLENUM PUBLISHERSNEW YORK, 2012)
Monocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the ...