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Modulation of Tau Isoforms Imbalance Precludes Tau Pathology and Cognitive Decline in a Mouse Model of Tauopathy
(Elsevier, 2018-04)
The microtubule-associated protein tau regulates myriad neuronal functions, such as microtubule dynamics, axonal transport and neurite outgrowth. Tauopathies are neurodegenerative disorders characterized by the abnormal ...
Modulación de isoformas de la proteína asociada a microtúbulos TAU: rescate de fenotipos moleculares y funcionales en un modelo murino de taupatíaModulation of microtubule associated protein tau isoforms: rescue of functional and molecular phenotypes in a mouse model of tauopathy
(2019-03-07)
Las enfermedades neurodegenerativas pueden ser causadas por una miríada de factores que conllevan a la muerte y/o disfunción de determinadas neuronas del cerebro humano. La enfermedad de Alzheimer (EA) y otras demencias ...
Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing
(Oxford University Press, 2013-07)
Abnormal metabolism of the tau protein is central to the pathogenesis of a number of dementias, including Alzheimer's disease. Aberrant alternative splicing of exon 10 in the tau pre-mRNA resulting in an imbalance of tau ...
Investigation of C9orf72 in 4 neurodegenerative disorders
(2012)
Objective: To estimate the allele frequency of C9orf72 (G4C 2) repeats in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), Alzheimer disease (AD), and Parkinson disease (PD). Design: The number ...
Search of brain-enriched proteins in salivary extracellular vesicles for their use as mental disease biomarkers: A pilot study of the neuronal glycoprotein M6a
(Elsevier, 2020-12)
Background: Mental disorders affect millions of people worldwide. Their etiology is complex and the fact that the main effects occur in the brain hampers biochemical diagnosis. Therefore, biomarker finding in peripheral ...
Análisis del efecto neuroprotector de agonistas de receptores nucleares en modelo farmacológico de Parkinson en neuronas dopaminérgicas.
(Universidad Nacional de Colombia - Sede Bogotá, 2019-12-10)
La enfermedad de Parkinson (EP) es la segunda patología neurodegenerativa más prevalente a nivel mundial se caracteriza por la muerte sistemática de las neuronas de la SNpc, la cual se ha vinculado al estrés oxidativo y ...