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Novel Role for Lysophosphatidic Acid in Vascular Remodeling at the Maternal-Fetal Interface
(BioScientifica, 2019-08)
Lysophosphatidic acid (LPA) belongs to the group of phosphorylated lipids reported as crucial mediators in the physiology of reproduction. LPA binds to G-protein coupled receptors and regulates a wide range of female ...
Steroid hormones induce in vitro human first trimester trophoblast tubulogenesis by the lysophosphatidic acid pathway
(Elsevier Ireland, 2018-12)
Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Progesterone (P4) and estradiol (E2) control many of the placental ...
Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus
(Elsevier, 2013-06)
Introduction: The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 ...
Lysophosphatidic acid-triggered pathways promote the acquisition of trophoblast endovascular phenotype in vitro
(Wiley-liss, Div John Wiley & Sons Inc, 2018-01)
Successful implantation and placentation requires that extravillous cytotrophoblast acquires an endovascular phenotype and remodels uterine spiral arteries. Defects in this mechanism correlate with severe obstetric ...
Metabolic pathways for the degradation of phosphatidic acid in isolated nuclei from cerebellar cells
(Elsevier, 2011-03)
The aim of the present research was to analyse the pathways for phosphatidic acid metabolism in purified nuclei from cerebellar cells. Lipid phosphate phosphatase and diacylglyceride lipase activities were detected in ...
Involvement of Lysophosphatidic Acid, Sphingosine 1-Phosphate and Ceramide 1-Phosphate in the Metabolization of Phosphatidic Acid by Lipid Phosphate Phosphatases in Bovine Rod Outer Segments
(Springer/Plenum Publishers, 2008-07)
The aim of the present research was to evaluate the generation of [2-3H]diacylglycerol ([2-3H]DAG) from [2-3H]-Phosphatidic acid ([2-3H]PA) by lipid phosphate phosphatases (LPPs) at different concentrations of lysophosphatidic ...