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Lorcaserin improves glycemic control via a melanocortin neurocircuit
(Elsevier Gmbh, 2017-10)
Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the ...
Lorcaserin Administration has Pro-Ejaculatory Effects in Rats via 5-HT2C Receptors Activation: A Putative Pharmacologic Strategy to Delayed Ejaculation?
(2020-06-01)
Background: Lorcaserin is an anti-obesity drug whose weight loss effect results from 5-hydroxytryptamin (5-HT)2C receptors activation. The 5-HT2C receptor was shown to participate in the physiological control of ejaculation, ...
Approaches for the development of drugs for treatment of obesity and metabolic syndrome
(Bentham Science Publishers, 2016)
Ghrelińs Orexigenic Effect Is Modulated via a Serotonin 2C Receptor Interaction
(American Chemical Society, 2015-07)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically ...
Síntesis, relaciones estructura/afinidad 5-ht2c y estudios computacionales de análogos del Anorexígeno lorcaserina.
(Universidad de Chile, 2018-12)
La lorcaserina ((1R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzazepina) es un nuevo
medicamento desarrollado por Smith y Smith en 2005 y aprobado por la FDA el año 2012 como
supresor del apetito. Esta droga actúa a ...
5-HT obesity medication efficacy via POMC activation is maintained during aging
(Endocrine Society, 2014-07-22)
The phenomenon commonly described as the middle-age spread is the result of elevated adiposity accumulation throughout adulthood until late middle-age. It is a clinical imperative to gain a greater understanding of the ...
Progressos recentes e novas perspectivas em farmacoterapia da obesidade
(Sociedade Brasileira de Endocrinologia e Metabologia, 2010)
O aumento da prevalência da obesidade, nas últimas décadas, é alarmante, o que implica um grande número de pacientes sob risco de complicações metabólicas e cardiovasculares associadas. A eficácia modesta a longo prazo das ...
Aproximaciones farmacológicas para el tratamiento de la obesidad
(Universidad Nacional de Colombia - Sede Bogotá - Facultad de Ciencias - Departamento de Farmacia, 2017-01-01)
La obesidad es uno de los más serios problemas del siglo XXI y se piensa que afecta a cerca de 300 millones de personas en todo el mundo. Según la Organización para la Cooperación y el Desarrollo Económico (OCDE), el 18% ...