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        A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages 

        Catalan-Figueroa, Johanna; Boisset, Constanza B.; Jara, Miguel O.; Flores, Mario E.; Moreno-Villoslada, Ignacio; Fiedler, Jenny L.; Morales, Javier O. (Elsevier B.V., 2018)
        © 2018 Elsevier B.V. Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In ...

        Loperamide mobilizes intracellular Ca 2+ stores in insulin-secreting HIT-T15 cells 

        He, Li Ping; Mears, David; Atwater, Illani; Rojas, Eduardo; Cleemann, Lars (2003)
        1 We have investigated the effects of loperamide on intracellular Ca2+ stores and membrane K+ channels in insulin-secreting hamster insulinoma (HIT-T15) cells. 2 In cell-attached patch-clamp mode, loperamide (3 – 250 mM) ...

        Poloxamer 188-Coated Ammonium Methacrylate Copolymer Nanocarriers Enhance Loperamide Permeability across Pgp-Expressing Epithelia 

        Catalan Figueroa, Johanna Francesca; García Alcalde, Mauricio Andrés; Contreras, Pilar; Boisset, Constanza B.; Gonzalez, Pablo M.; Fiedler, Jenny; Perez, Mariela Fernanda (American Chemical Society, 2021-02)
        Loperamide is a μ-opioid agonist with poor gastrointestinal absorption, mainly because of its modest aqueous solubility and being a P-glycoprotein (Pgp) efflux substrate. Nevertheless, studies associated with therapeutic ...

        Refining the intestinal motility test in mice to reduce animal stress 

        Marona, H. R N; Lucchesi, M. B B (2014)

        Refining the intestinal motility test in mice to reduce animal stress 

        Universidade Estadual Paulista (Unesp) (2003-12-01)
        A new protocol using 3-h fast animal for intestinal motility test was developed in our laboratory aiming the 3R's concept to reduce the stress of animals. Our results may aid in formulating recommendations that can be ...

        Refining the intestinal motility test in mice to reduce animal stress 

        Universidade Estadual Paulista (Unesp) (2003-12-01)
        A new protocol using 3-h fast animal for intestinal motility test was developed in our laboratory aiming the 3R's concept to reduce the stress of animals. Our results may aid in formulating recommendations that can be ...

        A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages 

        Unknown author (2018)
        Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...

        A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages 

        Unknown author (2018)
        Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...

        A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages 

        Catalán-Figueroa, Johanna [Univ Mayor, Ctr Nanotecnol Aplicada, Santiago, Chile]; Fiedler, Jenny L. [Univ Mayor, Ctr Nanotecnol Aplicada, Santiago, Chile]; Boisset, Constanza B.; Jara, Miguel O.; Flores, Mario E.; Moreno-Villoslada, Ignacio; Morales, Javier O. (ELSEVIER SCIENCE BV, 2018)
        Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium ...

        Protocol to refine intestinal motility test in mice 

        Universidade Estadual Paulista (Unesp) (2004-07-01)
        We propose a new protocol intended to conform to the 3Rs (replacement, reduction, and refinement) principle, using animals fasted for 3 h to control intestinal motility, which reduced stress in the animals. In this new ...
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        Red de Repositorios Latinoamericanos
        + of 4.000.000
        Available publications
        163 Participating institutions
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Membership Login
        Featured collections
        • Latin American Theses
        • Argentinean Theses
        • Chilean Theses
        • Peruvian Theses
        Latest collections added
        • Argentina
        • Brazil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018