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Neosaxitoxin, a Paralytic Shellfish Poison toxin, effectively manages bucked shins pain, as a local long-acting pain blocker in an equine model
(Pergamon-Elsevier Science LTD, 2018)
Local anesthesia is an effective method to control pain. Neosaxitoxin is a phycotoxin whose molecular mechanism includes a reversible inhibition of voltage gated sodium channels at the axonal level, impeding nerve impulse ...
First evidence of neosaxitoxin as a long-acting pain blocker in bladder pain syndrome
(Springer, 2015)
Introduction and hypothesis Neosaxitoxin is a phycotoxin
whose molecular mechanism of action shows a reversible
inhibition of voltage-gated sodium channels at the axonal level,
impeding nerve impulse propagation. This ...
Gonyautoxins: First evidence in pain management in total knee arthroplasty
(Pergamon-Elsevier Science Ltd., 2016)
Improvements in pain management techniques in the last decade have had a major impact on the practice of total knee arthroplasty (TKA). Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block ...
Neosaxitoxin, a Long-Lasting Local Anesthetic and its Potential Clinical Applications in Horses
(Faculty of Veterinary Sciences - Universidad Austral de Chile, 2023)
The peripheral L-arginine-nitric oxide-cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats
(LIPPINCOTT WILLIAMS & WILKINSPHILADELPHIA, 2012)
Crotalphine, a 14 amino acid peptide first isolated from the venom of the South American rattlesnake Crotalus durissus terrificus, induces a peripheral long-lasting and opioid receptor-mediated antinociceptive effect in a ...
Efeito antinociceptivo da toxina TX3-3 isolada do veneno da aranha Phoneutria nigriventer em modelos animais de dor
(Universidade Federal de Minas GeraisUFMG, 2010-12-10)
Venom peptides have produced exceptional lead compouds for drug development to treat pain. In the present study, we examined the antinociceptive and motor effects of Tx3-3, a peptide toxin isolated from Phoneutria nigriventer ...
Reorientación del esfuerzo terapéutico en neonatos al final de la vida: una revisión de alcance
Background: Reorientation of therapeutic efforts seeks to provide comfort measures to patients and relatives during the end of life stage; however, there are no standardized guidelines or protocols to guide health professionals ...
Identificación de mutaciones en genes asociados a canalopatías hereditarias mediante análisis exómico
(Universidad Nacional de ColombiaBogotá - Ciencias - Doctorado en Ciencias - BiologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2023-05-31)
El estudio de muerte súbita cardiaca es muy importante, dada la alta incidencia a nivel mundial, y en los países industrializados se ha convertido un problema de salud pública. Sin embargo, el abordaje de este tipo de ...