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In silico prediction of P-glycoprotein binding: Insights from molecular docking studies
(Bentham Science Publishers, 2019)
Differential effects of TR ligands on hormone dissociation rates: Evidence for multiple ligand entry/exit pathways
(Elsevier, 2009-11)
Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself. This result was interpreted to mean that ...
Differential effects of TR ligands on hormone dissociation rates: Evidence for multiple ligand entry/exit pathways
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Some nuclear receptor (NR) ligands promote dissociation of radiolabeled bound hormone from the buried ligand binding cavity (LBC) more rapidly than excess unlabeled hormone itself This result was interpreted to mean that ...
Only subtle protein conformational adaptations are required for ligand binding to thyroid hormone receptors: Simulations using a novel multipoint steered molecular dynamics approach
(AMER CHEMICAL SOC, 2008)
Thyroid hormone receptors (TR) are hormone-dependent transcription regulators that play a major role in human health, development, and metabolic functions. The thyroid hormone resistance syndrome, diabetes, obesity, and ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SPRINGER, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SpringerHeidelberg, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
Impact of human galectin-1 binding to saccharide ligands on dimer dissociation kinetics and structure
(Oxford University Press, 2016-12-05)
Endogenous lectins can control critical biological responses, including cell communication, signaling, angiogenesis and immunity by decoding glycan-containing information on a variety of cellular receptors and the extracellular ...
Intervening in the β-barrel structure of lipid binding proteins: Consequences on folding, ligand-binding and aggregation propensity
(Elsevier, 2015-02)
Natural β-folds manage to fold up successfully. By contrast, attempts to dissect fragments or peptides from well folded β-sheet proteins have met with insurmountable difficulties. Here we briefly review selected successful ...