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Overexpression of CYP19A1 aromatase in Leydig cells is associated with steroidogenic dysfunction in subjects with Sertoli cell-only syndrome
(Blackwell Publishing Ltd, 2017)
© 2016 American Society of Andrology and European Academy of Andrology Several observational studies have showed a combination of lower testosterone (T) to LH ratio and higher estradiol (E2) to T ratio in secretory infertile ...
Testicular steroid sulfatase overexpression is associated with Leydig cell dysfunction in primary spermatogenic failure
(Wiley, 2021)
Background Decreased testosterone (T) to LH ratio and increased 17 beta-estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell ...
Leydig cell dysfunction is associated with post-transcriptional deregulation of CYP17A1 in men with sertoli cell-only syndrome
(Oxford Univ. Press, 2018-04)
STUDY QUESTION: Is the expression of steroidogenic enzyme 17 alpha-Hydroxylase/17,20-Lyase (CYP17A1) down-regulated in Leydig cells (LCs) of men with spermatogenic failure and compensated impairment of LC function, i.e. a ...
Modulatory effects of leptin on Leydig cell function from normal and hiperleptinemic rats
(Karger, 2003-12)
Neonatal L-monosodium glutamate (MSG) administration in rats induces several neuroendocrine and metabolic disruptions. Leptin, the adipocyte product, modulates several neuroendocrine systems including the hypothalamic-pituitary- ...
P450-aromatase activity and expression in human testicular tissues with severe spermatogenic failure
(Blackwell Publishing Ltd, 2010)
There is evidence that impaired spermatogenesis is associated with an imbalance in the oestradiol/testosterone ratio and with Leydig cell (LC) dysfunction. In testis, P450-aromatase, encoded by CYP19, is responsible for ...
Análise morfofuncional e imuno-histoquímica das células de Leydig e dos macrófagos testiculares em ratos, após a exposição à nicotina durante as fases pré-natal e de lactação
(Universidade Federal de São Paulo (UNIFESP), 2010-09-29)
Nicotine is largely consumed by worldwide people since it is a component of cigarettes. It reaches the maternal milk and is able to cross the placental membrane. Nicotine induces apoptosis in different cell types and ...
Histamine H4 receptor as a novel therapeutic target for the treatment of Leydig-cell tumours in prepubertal boys
(Elsevier, 2018-03)
Leydig-cell tumours (LCTs) are rare endocrine tumours of the testicular interstitium, with recent increased incidence. Symptoms include precocious puberty in children; and erectile dysfunction, infertility and/or gynaecomastia, ...
Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc
(Elsevier Ireland, 2012-09)
Cisplatin (Cs) is a chemotherapeutic agent able to generate reactive oxygen species (ROS) which are linked to several side effects of the drug. Even when it is known that Cs produces Leydig cell dysfunction, it is unknown ...
Low risk of impaired testicular sertoli and Leydig cell functions in boys with isolated hypospadias
(ENDOCRINE SOC., 2005-11)
Testicular dysfunction was observed in 57.1% and androgen end- organ defects in 7.2% of patients with hypospadias associated with cryptorchidism, micropenis, or ambiguous genitalia. In the remaining 35.7%, the disorder was ...
Efeito do extrato de Ginkgo Biloba (EGb) sobre o sistema reprodutor masculino de ratos Wistar adultos
(Universidade Federal de Juiz de ForaBrasilFaculdade de MedicinaPrograma de Pós-graduação em Saúde BrasileiraUFJF, 2016)