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Glycoprotein hormone receptor knockdown leads to reduced reproductive success in male Aedes aegypti
(2019-01-01)
Glycoprotein hormone receptors mediate a diverse range of physiological functions in vertebrate and invertebrate organisms. The heterodimeric glycoprotein hormone GPA2/GPB5 and its receptor LGR1, constitute a recently ...
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing
(2015-10)
How different organs in the body sense growth perturbations in distant tissues to coordinatetheir size during development is poorly understood. Here we mutate an invertebrate orphanrelaxin receptor gene, the Drosophila ...
The biology and evolution of the Dilp8-Lgr3 pathway: A relaxin-like pathway coupling tissue growth and developmental timing control
(Elsevier Science, 2018-12-30)
Many insects, like cockroaches, moths, and flies, can regenerate tissues by extending the growth-competent phases of their life cycle. The molecular and cellular players mediating this coordination between tissue growth ...
R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development
(John Wiley & Sons Inc, 2020-08)
The mammary gland is a secretory organ, which develops as a network of growing epithelial ducts composed of luminal and basal cells that invade the surrounding adipose tissue through a series of developmental cycles. Mammary ...
Determinación de mutaciones en el gen INSL3 y de la mutación A664C (T222P) en el GEN LGR8, en pacientes colombianos con Criptorquidia y en un grupo control
(2010)
La criptorquidia –descenso defectuoso o incompleto del testículo desde su origen hasta su situación definitiva en la bolsa escrotal– representa el trastorno más frecuente de la diferenciación sexual en los varones. Al ...