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In vitro evaluation of leptin fragments activity on the ob receptor
(Wiley-Blackwell, 2008-05-01)
In an attempt to identify regions in the leptin molecule responsible for its bioactivity, we tested six related-leptin peptide fragments denoted: Ae-hLEP(23-47)-NH(2) (I), Ac-hLEP(48-71)-NH(2) (II), Ac-hLEP(72-88)-NH(2) ...
Is “Leptin Resistance” Another Key Resistance to Manage Type 2 Diabetes?
(Bentham Science Publishers, 2020)
Although novel pharmacological options for the treatment of type 2 diabetes mellitus (DM2) have been observed to modulate the functionality of several key organs in glucose homeostasis, successful regulation of insulin ...
Effects of treatment with leptin-like peptides on factors related to body fat control in Wistar rats fed a high-fat diet.
(2011-11-10)
Introduction: The results of administering recombinant leptin, as well as the 116-130 peptide of mouse leptin in ob/ob
mice have shown the probability of discovering more efficient leptin-based therapeutic methods to treat ...
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
(Nature Publishing Group, 2001-05)
The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is associated with elevated leptin, which suggests that obese ...
Regulation of placental leptin expression by cyclic adenosine 5′-monophosphate involves cross talk between protein kinase A and mitogen-activated protein kinase signaling pathways
(Endocrine Society, 2010-08)
Leptin, a 16-kDa protein mainly produced by adipose tissue, has been involved in the control of energy balance through its hypothalamic receptor. However, pleiotropic effects of leptin have been identified in reproduction ...
Fat Body p53 Regulates Systemic Insulin Signaling and Autophagy under Nutrient Stress via Drosophila Upd2 Repression
(Elsevier, 2020-10)
The tumor suppressor p53 regulates multiple metabolic pathways at the cellular level. However, its role in the context of a whole animal response to metabolic stress is poorly understood. Using Drosophila, we show that ...
Hypothalamic S1p/s1pr1 Axis Controls Energy Homeostasis
(Nature Publishing Group, 2014)
Appetite Is Suppressed After Full-Body Resistance Exercise Compared With Split-Body Resistance Exercise: The Potential Influence of Lactate and Autonomic Modulation
(2021-09-01)
ABSTRACT: Conrado de Freitas, M, Ricci-Vitor, AL, de Oliveira, JVNS, Quizzini, GH, Vanderlei, LCM, Silva, BSA, Zanchi, NE, Cholewa, JM, Lira, FS, and Rossi, FE. Appetite is suppressed after full-body resistance exercise ...
Regulation of glucose metabolism in neurons by adiponectin and resistin, a possible molecular link between brain dysfunction and obesity
(2018)
The brain is an organ with a high rate of glucose consumption and in several disorders, it has
been described a decrease in the brain capacity to utilize glucose including in Alzheimer´s
disease (AD) and obesity. Despite ...