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Production of β-lactamase inhibitors by Streptomyces species
(2018-09-01)
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials ...
β -lactamase-mediated Resistance: A Biochemical, Epidemiological and Genetic Overview
(Bentham Science Publ Ltd, 2013-01)
Early after the introduction of the first (narrow spectrum) penicillins into clinical use, penicillinase-producing staphylococci replaced (worldwide) the previously susceptible microorganisms. Similarly, the extensive use ...
Beta-lactamase detection in Staphylococcus aureus and coagulase-negative Staphylococcus isolated from bovine mastitis
(Colégio Brasileiro de Patologia Animal - CBPA, 2014-04-01)
The objectives of the study were to evaluate the presence/production of beta-lactamases by both phenotypic and genotypic methods, verify whether results are dependent of bacteria type (Staphylococcus aureus versus ...
Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru
(MDPI, 2021)
Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment ...
In silico mutations of TEM-1 β-lactamase show changes in structure and drug-enzyme affinity binding by molecular docking
(2016)
Bacterial resistance refers to bacteria capacity to evade antibiotic action, which constitutes a public
health issue. This resistance is given by β-lactamase enzymes that break the drug rings and alter its function. To ...
Structural insights into the inhibition of the extended-spectrum -lactamase PER-2 by avibactam
(American Society for Microbiology, 2019-08)
The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-lactamases. Previous investigations showed that inhibition constants of AVI toward class A PER-2 are reminiscent of values observed for class ...