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Lysosomal permeabilization and endoplasmic reticulum stress mediate the apoptotic response induced after photoactivation of a lipophilic zinc(II) phthalocyanine
(Pergamon-Elsevier Science Ltd, 2018-10)
We have previously reported that the phototoxic action of the lipophilic phthalocyanine Pc9 (2,9(10),16(17),23(24) tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)) encapsulated into poloxamine micelles is ...
Lysosomal and mitochondrial permeabilization mediates zinc(II) cationic phthalocyanine phototoxicity
(Elsevier, 2013-11)
In order to find a novel photosensitizer to be used in photodynamic therapy for cancer treatment, we have previously showed that the cationic zinc(II) phthalocyanine named Pc13, the sulfur-linked dye 2,9(10),16(17),23(24 ...
The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity
(Elsevier Science, 2015-07)
P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1-P5. The ion transported by the P5-ATPases is not known. Five genes named ATP13A1-ATP13A5 that belong to the P5-ATPase ...
Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Crotamine, one of the main toxic components of Crotalus durissus terrificus venom, is a small non-enzymatic basic polypeptide, which causes hind limb paralysis and necrosis of muscle cells. it is well-known that several ...
Pre-clinical antitumour evaluation of Biphosphinic Palladacycle Complex in human leukaemia cells
(Elsevier Ireland LtdClareIrlanda, 2009)
Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus
(Company of Biologists, 2018-10-25)
Neuronal excitotoxicity induced by glutamatergic receptor overstimulation contributes to brain damage. Recent studies have shown that lysosomal membrane permeabilization (LMP) is involved in ischemia-associated neuronal ...
Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells
(Elsevier B.V., 2006-08-07)
The cell death mechanism of cytotoxicity induced by the Biphosphinic Palladacycle Complex (BPC) was studied using a K562 leukaemia cell line. the IC50 values obtained for K562 cells post-72 h of BPC were less than 5.0 mu ...
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1
(Amer Assoc Advancement Science, 2021)
Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM1 (transmembrane BAX ...