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Neutrophils exhibit differential requirements for homing molecules in their lymphatic and blood trafficking into draining lymph nodes
(American Association of Immunologists, 2014-07)
Although much is described about the molecules involved in neutrophil migration from circulation into tissues, less is known about the molecular mechanisms that regulate neutrophil entry into lymph nodes (LNs) draining a ...
Migratory capacity and function of dendritic cells from mesenteric afferent lymph nodes after feeding a single dose of vitamin A
(Elsevier Science Inc, 2017-11-24)
Lamina propria dendritic cells (DCs) have a permanent turnover with constitutive migration to mesenteric lymph nodes and replenishment by progenitors. Luminal bacteria and dietary constituents provide key signals that endow ...
Cytokine-enhanced maturation and migration to the lymph nodes of a human dying melanoma cell-loaded dendritic cell vaccine
(Springer, 2015-06)
Dendritic cells (DCs) are professional APCs used for the development of cancer vaccines because of their ability to activate adaptive immune responses. Previously, we designed the DC/Apo-Nec vaccine using human DCs loaded ...
Immature myeloid Gr-1+ CD11b+ cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function
(Portland Press, 2016-01-14)
Secondary infections due to post-sepsis immunosuppression are a major cause of death in patients with sepsis.Repetitive inoculation of increasing doses of lipopolysaccharide (LPS) into mice mimics the immunosuppressionassociated ...
Dendritic cell-based vaccine efficacy: Aiming for hot spots
(Frontiers Research Foundation, 2015-03)
Many approaches for cancer immunotherapy have targeted dendritic cells (DCs), directly or indirectly, for the induction of antitumor immune responses. DC-based vaccines have been developed using a wide variety of ex vivo ...
Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
(AMER ASSOC IMMUNOLOGISTS, 2008-05-15)
It has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the ...
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
(2003)
Whereas naive T cells migrate only to secondary lymphoid
organs1,2, activation by antigen confers to T cells the ability to
home to non-lymphoid sites3,4. Activated effector/memory T cells
migrate preferentially to ...
Linfócitos T CD4+ e CD8+ participam da resposta imune de memória contra a infecção humana natural pelo vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2013-12-18)
The present study evaluates the immune response of memory CD4+ and CD8+ T cells from patients following a natural Vaccinia virus (VACV) infection. A total of 42 individuals were involved in the study being: 22 previously ...
Elevada concentração de glicose altera a resposta biológica de linhagem de células dendríticas murina
(Universidade Estadual Paulista (Unesp), 2016-07-21)
Diabetes mellitus (DM) é uma desordem metabólica importante caracterizada pela ausência de secreção e/ou ação deficiente da insulina, resultando em hiperglicemia crônica e persistente que é a principal característica do ...
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X(7) receptors
(2017)
Upon its release frominjured cells, such as infected, transformed, inflamed, or necrotic cells, extracellular adenosine-5'-triphosphate (ATP) acts as a danger signal that recruits phagocytes, such as neutrophils, macrophages, ...