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Lrig1 and lrig3 cooperate to control ret receptor signaling, sensory axonal growth and epidermal innervations
(Company of Biologists, 2021-08)
Negative feedback loops represent a regulatory mechanism that guarantees that signaling thresholds are compatible with a physiological response. Previously, we established that Lrig1 acts through this mechanism to inhibit ...
Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling
(Nature Publishing Group, 2016-04)
Even though many extracellular factors have been identified as promoters of general dendritic growth and branching, little is known about the cell-intrinsic modulators that allow neurons to sculpt distinctive patterns of ...
LRIG1 negatively regulates RET mutants and is downregulated in thyroid cancer
(Spandidos Publications, 2018-04)
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 ...
Regulación negativa de las señales inducidas por los factores neurotróficos y sus receptores en neuronas en desarrolloNegative regulation of neurotrophic factor receptor signaling in developing neurons
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2015)
High Plasticity of New Granule Cells in the Aging Hippocampus
(Elsevier Science, 2017-10)
During aging, the brain undergoes changes that impair cognitive capacity and circuit plasticity, including a marked decrease in production of adult-born hippocampal neurons. It is unclear whether development and integration ...
Efectos del envejecimiento en la maduración e integración funcional de células granulares nacidas en el hipocampo adultoEffects of aging on the maturation and functional integration of adult-born dentate granule cells
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2015)