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A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome
(2011)
The severity of attention-deficit/hyperactivity disorder (ADHD) symptoms is a major predictor of long-term ADHD outcome. To investigate if two-locus interactions might predict ADHD severity, we studied a sample of 1341 ...
Screening of human LPHN3 for variants with a potential impact on ADHD susceptibility
(Wiley-liss, Div John Wiley & Sons Inc, 2011-01)
Attention deficit hyperactivity disorder (ADHD) is the most common behavioral disorder in childhood, and often has effects detectable into adulthood. Advances in genetic linkage and association analysis have begun to ...
A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication
(Nature Publishing Group, 2010-11)
Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches ...
Genetic variation underpinning ADHD risk in a caribbean community
(Published by MDP, 2019)
Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent
neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic
studies indicates that single nucleotide ...
An Ultraconserved brain-specific enhancer within ADGRL3 (LPHN3) underpins attention-deficit/hyperactivity disorder susceptibility
BACKGROUND—Genetic factors predispose to attention deficit/hyperactivity disorder (ADHD). Previous studies have reported linkage and association to ADHD of gene variants within ADGRL3. In this study, we functionally analyzed ...
ADGRL3 (LPHN3) variants predict substance use disorder
(Nature Research, 2019-01)
Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attentiondeficit/
hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use ...
ADGRL3 (LPHN3) variants predict substance use disorder
Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use ...
Avaliação da teneurina-2 em astrócitos reativos no modelo experimental de epilepsia induzida com cloreto de lítio-cloridrato de pilocarpina em ratos adultos. Análises imunoistoquímica, histoquímica e de expressão gênica
(Universidade Estadual Paulista (Unesp), 2019-12-02)
As teneurinas (Tens) são proteínas transmembrana do tipo II, constituídas de quatro membros homólogos (Ten-1-4). Estas proteínas são expressas principalmente durante a neurogênese do sistema nervoso central (SNC) e estão ...
A putative role of teneurin-2 and its related proteins in astrocytes
(2019-01-01)
Teneurins are type II transmembrane proteins comprised of four phylogenetically conserved homologs (Ten-1-4) that are highly expressed during neurogenesis. An additional bioactive peptide named teneurin C-terminal-associated ...
Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate
Attention-deficit/hyperactivity disorder (ADHD) is a heritable, chronic, neurodevelopmental disorder with serious long-term repercussions. Despite being one of the most common cognitive disorders, the clinical diagnosis ...