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Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systems
(Elsevier Ireland, 2002-11)
Liver microsomal (mic); nuclei (N) and mitochondria (mit) anaerobically nitroreduce Nifurtimox (Nfx) in the presence of NADPH generating system. Simultaneous formation of small amounts of nitrite was observed in microsomes ...
Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet
(Sage Publications, 2006-10-01)
In previous studies from our laboratory, the presence in highly purified liver nuclei of metabolic pathways for processing ethanol (EtOH); N-nitrosodimethylamine (NDMA); carbon tetrachloride and chloroform was reported. ...
Methionine aminopeptidase associated with liver mitochondria and microsomes
(Elsevier B.V., 1981-01-01)
A new, unstable, particle-bound (particularly mitochondria and microsomes) aminopeptidase, mol. wt 74,000, was partially purified from rat liver. Among five aminoacyl-β-naphthylamides assayed, MetNA was the best substrate. ...
Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals
(Elsevier Ireland, 2002-03)
Recent studies from other laboratories reported that during methanol intoxication lipid peroxidation and protein oxidation in liver occurred. Further, they detected free radicals-PBN adducts in bile and urine of methanol ...
Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet
(Sage Publications Ltd, 2008-11)
Highly purified rat-liver nuclei were previously shown to have nuclear ethanol (EtOH) metabolizing system able to bioactivate alcohol to acetaldehyde and 1-hydroxyethyl radicals. These reactive metabolites were able to ...
Alcohol induction of liver nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites
(Wiley, 2002-01)
In previous studies from our laboratory we reported the presence in highly purified liver nuclei, free of contamination with other organelles, of an ethanol metabolizing system (NEMS) able to lead to acetaldehyde and ...
Aromatic antiepileptic drugs and mitochondrial toxicity: Effects on mitochondria isolated from rat liver
(Pergamon-Elsevier B.V. Ltd, 2008-08-01)
Idiosyncratic hepatotoxicity is a well-known complication associated with aromatic antiepileptic drugs (AAED), and it has been suggested to occur due to the accumulation of toxic arene oxide metabolites. Although there is ...