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Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions
(2010)
Lipins constitute a novel family of Mg2+-dependent phosphatidate phosphatases that catalyze the dephosphorylation of phosphatidic acid to yield diacylglycerol, an important intermediate in lipid metabolism and cell signaling. ...
Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions
(WILEY-BLACKWELL PUBLISHING, INC, 2010)
Lipins constitute a novel family of Mg2+-dependent phosphatidate phosphatases that catalyze the dephosphorylation of phosphatidic acid to yield diacylglycerol, an important intermediate in lipid metabolism and cell signaling. ...
The catalytic efficiency of Lipin 1beta increases by physically interacting with the protooncoprotein c-Fos
(American Society For Biochemistry And Molecular Biology, 2015-10)
Phosphatidic acid (PA) is a central precursor for membrane phospholipid biosynthesis. Lipin family is a Mg-dependent type I PA phosphatase,involved in de novo synthesis of neutral lipids and of phospholipids. The regulation ...
TAG synthesis and storage under osmotic stress. A requirement for preserving membrane homeostasis in renal cells
(Elsevier Science, 2018-09-14)
Hyperosmolarity is a controversial signal for renal cells. It can induce cell stress or differentiation and both require an active lipid metabolism. We showed that hyperosmolarity upregulates phospholipid (PL) de novo ...
Circadian Regulation and Clock-Controlled Mechanisms of Glycerophospholipid Metabolism from Neuronal Cells and Tissues to Fibroblasts
(Humana Press, 2021-10-26)
Along evolution, living organisms developed a precise timekeeping system, circadian clocks, to adapt life to the 24-h light/dark cycle and temporally regulate physiology and behavior. The transcriptional molecular circadian ...
X-box binding protein 1 (XBP1): A key protein for renal osmotic adaptation: Its role in lipogenic program regulation
(Elsevier Science, 2020-04)
In renal cells, hyperosmolarity can induce cellular stress or differentiation. Both processes require active endoplasmic reticulum (ER)-associated protein synthesis. Lipid biosynthesis also occurs at ER surface. We showed ...
Mecanismo molecular de la activación de la síntesis de fosfolípidos por la proto-oncoproteína c-Fos
(2015-06-08)
La proto-oncoproteína c-Fos es un factor de transcripción tipo AP-1 cuya función fue descripta hace más de 25 años (Curran & Morgan 1987). En su función canónica, c-Fos forma heterodímeros funcionales con proteínas de las ...
Mecanismo molecular de la activación de la síntesis de fosfolípidos por la proto-oncoproteína C-Fos
(2015)
La proto-oncoproteína c-Fos es un factor de transcripción tipo AP-1 cuya función fue
descripta hace más de 25 años (Curran & Morgan 1987). En su función canónica, c-Fos forma
heterodímeros funcionales con proteínas de ...