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Recent advances in siRNA delivery mediated by lipid-based nanoparticles
Small interfering RNA (siRNA) has been expected to be a unique pharmaceutic for
the treatment of broad-spectrum intractable diseases. However, its unfavorable properties
such as easy degradation in the blood and ...
Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle
mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement
therapy, cancer immunotherapy, immune cell engineering etc. However, optimization of mRNA molecules and
efficient ...
Preparation, physicochemical and biopharmaceutical characterization of oxcarbazepine-loaded nanostructured lipid carriers as potential antiepileptic devices
(Editions Sante, 2021-06)
Epilepsy is the second most common chronic central nervous system disorder. Oxcarbazepine (OXC) is an antiepileptic drug with low solubility in aqueous media but is used for the treatment of both focal and generalized ...
A thermostable mRNA vaccine against COVID-19
There has been an urgent need of vaccines against coronavirus disease 2019 (COVID-19) due to
the ongoing SARS-CoV-2 pandemic. Among all approaches, messenger RNA (mRNA) -based
vaccine has emerged as a rapid and versatile ...
A thermostable mRNA vaccine against COVID-19
(Elsevier, 2020)
Nanopartículas lipídicas para liberação de ácidos nucleicos: uma revisão da literatura
(Florianópolis, SC., 2022)