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The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms
(Wiley Blackwell Publishing, Inc, 2017-12)
Neurotensin is known to inhibit neuronal Na+, K+‐ATPase, an effect that is rescued by nitric oxide (NO) synthase inhibition. However, whether the neurotensinergic and the nitrergic systems are independent pathways, or are ...
The administration of levocabastine, a NTS2 receptor antagonist, modifies Na+, K+-ATPase properties
(Springer, 2016-06)
Neurotensin behaves as a neuromodulator or as a neurotransmitter interacting with NTS1 and NTS2 receptors. Neurotensin in vitro inhibits synaptosomal membrane Na+, K+-ATPase activity. This effect is prevented by administration ...
High affinity receptors but not low affinity receptors for neurotensin are involved in neuronal Na/K-ATPase inhibition by the peptide
(Research Trends, 2013-07)
Neurotensin acts as a neuromodulator or as a neurotransmitter that binds to a group of receptors. Two of the receptors, namely NTS1 and NTS2, bind to neurotensin with high affinity and low affinity, respectively. Neurotensin ...
Brain mitochondria bioenergetics, nitrergic and neurotensinergic systems
(Nova Science Publishers, 2020)
Mitochondria display a central role in cellular activity, being essential for energetic metabolism, Ca2+ homeostasis and cell signalling. The brain is one of the organs with the highest oxygen consumption of the human body, ...
Neurotensin decreases high affinity [ 3H]-ouabain binding to cerebral cortex membranes
(Elsevier Science, 2011-12)
Previous work from this laboratory showed the ability of neurotensin to inhibit synaptosomal membrane Na +, K +-ATPase activity, the effect being blocked by SR 48692, a non-peptidic antagonist for high affinity neurotensin ...
Neurotensin inhibits neuronal Na+, K+-ATPase activity through high affinity peptide receptor
(Elsevier Science Inc, 2000)