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Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia
(BioScientifica, 2020-02)
Among all the hormone-secreting pituitary tumours, prolactinomas are the most frequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line ...
Role of GPER in the anterior pituitary gland focusing on lactotroph function
(BioScientifica, 2018-10)
Ovarian steroids control a variety of physiological functions. They exert actions throughclassical nuclear steroid receptors, but rapid non-genomic actions through specificmembrane steroid receptors have been also described. ...
Morphological and morphometric changes of pituitary lactotrophs of viscacha (Lagostomus maximus maximus) in relation to reproductive cycle, age, and sex
(Wiley-liss, div John Wiley & Sons Inc., 2010-02)
Lactotrophs in pituitary pars distalis (PD) of viscacha were studied by immunohistochemistry and morphometric analysis in the following groups: 1) adult males throughout the reproductive cycle (reproductive, gonadal ...
The phthalate DEHP modulates the estrogen receptors α and β increasing lactotroph cell population in female pituitary glands
(Pergamon-Elsevier Science Ltd, 2020-11)
Humans are exposed to numerous endocrine disruptors on a daily basis, which may interfere with endogenous estrogens, with Di-(2-ethylhexyl) phthalate (DEHP) being one of the most employed. The anterior pituitary gland is ...
Cadmium exposure modifies lactotrophs activity associated to genomic and morphological changes in rat pituitary anterior lobe
(Springer, 2010-02)
Cadmium (Cd) is widely used in industrial applications and is an important contaminant of agricultural products. As an endocrine disruptor, Cd modifies the hormone release of pituitary anterior lobe (PAL). This work ...
Activin-inhibitory action on lactotrophs is decreased lactotroph hyperplasia
(BioScientifica, 2019-12)
Among all the hormone-secreting pituitary tumours, prolactinomas are the mostfrequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line therapy. ...
Functional Toll-like receptor 4 expressed in lactotrophs mediates LPS-induced proliferation in experimental pituitary hyperplasia
(Elsevier Inc, 2013-11)
Toll like receptor 4 (TLR4) has been characterized for its ability to recognize bacterial endotoxin lipopolysaccharide (LPS). Considering that infections or inflammatory processes might contribute to the progression of ...
Effect of undernutrition on cranial components and somatotroph-lactotroph pituitary populations in the squirrel monkey (Saimiri sciureus boliviensis)
(Karger, 2001-04)
The aim of the present study was to investigate in monkeys the effects of undernutrition on neurocranial and facial components, correlated with a histometric and ultrastructural analysis of somatotroph (growth hormone, GH) ...
Cooperative effect of E2 and FGF2 on lactotroph proliferation triggered by signaling initiated at the plasma membrane
(American Physiological Society, 2013-04)
In the present work, we investigated the effect of 17β-estradiol (E2) and basic fibroblast growth factor 2 (FGF2) on the lactotroph cell-proliferative response and the related membrane-initiated signaling pathway. Anterior ...