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Genetically altered animal models in the kallikrein-kinin system
(Walter de Gruyter & Co, 2006-02-01)
Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin ...
Improvement of baculovirus as protein expression vector and as biopesticide by CRISPR/Cas9 editing
(John Wiley & Sons Inc, 2019-08)
The clustered regularly interspaced short palindromic repeats (CRISPR) system?associated Cas9 endonuclease is a molecular tool that enables specific sequence editing with high efficiency. In this study, we have explored ...
Avaliação de diferentes protocolos para edição gênica pela metodologia CRISPR/Cas9 em Leishmania amazonensis.
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Ciências FarmacêuticasUFMG, 2020-02-28)
The CRISPR/Cas9 system has been considered as a revolutionary tool to promote gene
edition in a wide array of organisms. The knockouts and knock-ins generated by CRISPR/Cas9
allow better understanding of cellular, metabolic ...
The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: Preclinical evidence for the treatment of skin inflammation
(Elsevier B.V., 2009-01-08)
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models in mice. Topical and i.p. application of kinin B(1) and B(2) receptor antagonists caused a significant inhibition of the ...
Efeito do nocaute da mitofusina 2 sobre a mitocôndria, o retículo endoplasmático e a mitofagia em oócitos murinos
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEvCâmpus São Carlos, 2018-08-24)
Mitofusins 1 (MFN1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and involved in the regulation of mitochondrial fusion. Since MFN2 is also present in the membrane of the endoplasmic ...
Cinética das espermatogônias em camundongos Knockout Tex14 com ausência de pontes intercelulares
(Universidade Federal de Minas GeraisUFMG, 2016-08-08)
Intercellular bridges are cytoplasmic channels that interconnect clones of germ cells in a syncytium. It has been predicted that the intercellular bridges have a fundamental role in the communication and synchronization ...
Selective Attention to Visual Stimuli Using Auditory Distractors Is Altered in Alpha-9 Nicotinic Receptor Subunit Knock-Out Mice
(Society for Neuroscience, 2016-07)
During selective attention, subjects voluntarily focus their cognitive resources on a specific stimulus while ignoring others. Top-downfiltering of peripheral sensory responses by higher structures of the brain has been ...