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Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
(2019)
Klotho is an aging-related protein associated with hippocampal cognitive performance in mammals. Klotho regulates progenitor cell proliferation in non-neuronal tissues, but its role in adult hippocampal neurogenesis (AHN) ...
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
(2019)
Klotho is an aging-related protein associated with hippocampal cognitive performance in mammals. Klotho regulates progenitor cell proliferation in non-neuronal tissues, but its role in adult hippocampal neurogenesis (AHN) ...
Rol de Klotho en la regulación de la neurogénesis hipocampal del adulto
(Universidad de Chile, 2015)
La población mundial envejece en forma acelerada. Considerando que el
deterioro cognitivo es uno de los principales determinantes de enfermedad y
discapacidad de los adultos mayores, la comprensión de sus mecanismos
f ...
Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
(National Academy of Sciences, 2017-01)
Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho down-regulates ...
Rol de Klotho y FGF23 en la regulación de fosfato y calcio plasmático
(Hospital Clínico Universidad de Chile, 2010)
Recently, two proteins have been discovered, named Klotho and FGF23, which are involved in several physiologic phenomena. One of the most relevant is the reduction of phosphatemia and the increase of phosphaturia. This ...
Thyroid hormone induced expression of the hepatic scaffold proteins sestrin2, beta Klotho, and FRS2 in relation to FGF21 AMPK signaling
(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg GMBH, 2018)
Thyroid hormone (3,3', 5-triiodothyronine, T-3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK). This study aims to assess the influence of T-3 ...
Avaliação dos níveis plasmáticos da proteína Klotho em idosos com transtorno depressivo maior e sua relação com comprometimento cognitivo
(Universidade Federal de Minas GeraisUFMG, 2017-06-29)
Major depressive disorder (MDD) is one of the most common psychiatric diseases among the elderly. It is well-known that a number of clinical disorders are related to or intensified by MDD, which impacts their quality of ...
Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling
(National Academy of Sciences, 2017)
Abstract: Soluble klotho, the shed ectodomain of the antiaging membrane protein α-klotho, is a pleiotropic endocrine/paracrine factor with no known receptors and poorly understood mechanism of action. Soluble klotho ...