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Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins
(ELSEVIER SCIENCE BV, 2008)
In the kallikrein-kinin and renin-angiotensin systems the main receptors, B-1 and B-2 (kinin receptors) and AT(1) and AT(2) (angiotensin receptors) respectively, are seven-transmembrane domain G-protein-coupled receptors. ...
Role of the kinin B-1 receptor in insulin homeostasis and pancreatic islet function
(Walter de Gruyter & Co, 2006-04-01)
Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive subtype B-2) and one inducible (subtype B-1), and ...
Kinin-B2 Receptor Mediated Neuroprotection after NMDA Excitotoxicity Is Reversed in the Presence of Kinin-B1 Receptor Agonists
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
Background: Kinins, with bradykinin and des-Arg(9)-bradykinin being the most important ones, are pro-inflammatory peptides released after tissue injury including stroke. Although the actions of bradykinin are in general ...
Molecular biology of the kallikrein-kinin system: from structure to function
(Associação Brasileira de Divulgação Científica, 1998-09-01)
The participation of the kallikrein-kinin system, comprising the serine proteases kallikreins, the protein substrates kininogens and the effective peptides kinins, in some pathological processes like hypertension and ...
Genetically altered animal models in the kallikrein-kinin system
(Walter de Gruyter & Co, 2006-02-01)
Transgenic and gene-targeting technologies allowing the generation of genetically altered animal models have greatly advanced our understanding of the function of specific genes. This is also true for the kallikrein-kinin ...
Swimming training exacerbates pathological cardiac hypertrophy in kinin B(2) receptor-deficient mice
(Elsevier B.V., 2008-02-01)
Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B(2) receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy ...
Swimming training exacerbates pathological cardiac hypertrophy in kinin B(2) receptor-deficient mice
(Elsevier B.V., 2008-02-01)
Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B(2) receptor activation. Chronic physical exercise can induce physiological cardiac hypertrophy ...
The non-peptide kinin receptor antagonists FR 173657 and SSR 240612: Preclinical evidence for the treatment of skin inflammation
(Elsevier B.V., 2009-01-08)
Peptide and non-peptide kinin receptor antagonists were evaluated in cutaneous inflammation models in mice. Topical and i.p. application of kinin B(1) and B(2) receptor antagonists caused a significant inhibition of the ...
Cross talk between kinin and angiotensin II receptors in mouse abdominal aorta
(Walter de Gruyter & Co, 2009-09-01)
Bradykinin (BK) is a vasorelaxant, algesic and inflammatory agent. Angiotensin II (AngII) is known to control vascular tone and promote growth, inflammation and artherogenesis. There is evidence for cross talking between ...
Kinin B-2 receptor deletion and blockage ameliorates cisplatin-induced acute renal injury
(Elsevier B.V., 2014-09-01)
Cisplatin treatment has been adopted in some chemotherapies; however, this drug can induce acute kidney injury due its ability to negatively affect renal function, augment serum levels of creatinine and urea, increase the ...