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Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(ELSEVIER IRELAND LTDCLARE, 2012)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. In fact, cells deficient for XPA ...
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(Elsevier B.V., 2012-01-01)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. in fact, cells deficient for XPA ...
Activation of the ET-1/ETA Pathway Contributes to Erectile Dysfunction Associated with Mineralocorticoid Hypertension
(WILEY-BLACKWELL PUBLISHING, INC, 2008)
The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive ...
Gene amplification is a mechanism of SW overexpression in breast cancer
(Amer Assoc Cancer ResearchPhiladelphiaEUA, 2005)
Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA
(National Academy of Sciences, 2012-05)
The checkpoint kinases Chk1 and ATR are broadly known for their role in the response to the accumulation of damaged DNA. Because Chk1 activation requires its phosphorylation by ATR, it is expected that ATR or Chk1 ...
Increased endothelin-1 reactivity and endothelial dysfunction in carotid arteries from rats with hyperhomocysteinemia
(WILEY-BLACKWELL PUBLISHING, INCEstados Unidos, 2009)
DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosurn
(NATL RESEARCH COUNCIL CANADA-N R C RESEARCH PRESS, 2008)
The penis is kept in the flaccid state mainly via a tonic activity of norepinephrine and endothelins (ETs). ET-1 is important in salt-sensitive forms of hypertension. We hypothesized that cavernosal responses to ET-1 are ...
Endothelin-1 Induces Contraction of Female Rat Internal Pudendal and Clitoral Arteries through ET(A) Receptor and Rho-Kinase Activation
(WILEY-BLACKWELL, 2010)
Introduction. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, acts mainly through the Gprotein-coupled ET(A) receptor (ET(A)R). Increased vascular ET-1 production and constrictor sensitivity have been observed in ...
Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing
(Nature Publishing Group, 2019-06)
The effectiveness of checkpoint kinase 1 (Chk1) inhibitors at killing cancer cells is considered to be fully dependent on their effect on DNA replication initiation. Chk1 inhibition boosts origin firing, presumably limiting ...
O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway
(OXFORD UNIV PRESS, 2011)
Aims Glycosylation with beta-N-acetylglucosamine (O-GlcNAcylation) is one of the most complex post-translational modifications. The cycling of O-GlcNAc is controlled by two enzymes: UDP-NAc transferase (OGT) and O-GlcNAcase ...