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Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy?
(2019-01-01)
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by extensive inflammation, demyelination, axonal loss and gliosis. Evidence indicates that mast cells contribute to ...
Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord
(Nature Publishing Group, 2020-01)
The aim of this work was to study effects of ketotifen fumarate (KF) on prevention of tissue damage in testes of rats with experimental autoimmune orchitis (EAO) and on the contralateral testis in a model of prolonged ...
Should mast cells be considered therapeutic targets in multiple sclerosis?
(2020-11-01)
Mast cells are immune cells of the myeloid lineage that are found throughout the body, including the central nervous system. They perform many functions associated with innate and specific immunity, angiogenesis, and ...
Efeito da estabilização de mastócitos no desenvolvimento da encefalomielite autoimune experimental
(Universidade Estadual Paulista (Unesp), 2017-06-08)
A Esclerose múltipla é uma doença autoimune degenerativa que acomete jovens adultos, causando danos neuroaxonais e áreas de desmielinização no sistema nervoso central (SNC) devido a uma resposta autoimune mediada por ...
Eficacia clínica del fumarato de ketotifeno en el tratamiento de la conjuntivitis alergica
(Universidad de La Salle. Ediciones Unisalle, 15 d)
Comparação do uso tópico de cetotifeno com a olopatadina no tratamento de conjuntivites alérgicas
(Conselho Brasileiro de Oftalmologia, 2001-10-01)
Purpose: To evaluate and compare the efficacy and tolerance to the topical use of 0.05% ketotifen fumarate and 0.1% olopatadine hydrochloride in the treatment of patients with allergic conjunctivitis. Methods: A masked, ...
delta-Lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity
(TAYLOR & FRANCIS LTDABINGDON, 2012)
From cultures of thermophilic soil fungus Humicola grisea var thermoidea, a delta-lactam derivative (3-(2-(4-hydroxyphenyl)-2-oxoethyl)-5,6-dihydropyridin-2( 1H)-one) that displayed anti-allergic activity was isolated, ...
Controle de qualidade na indústria farmacêutica: contribuição para a identificação de substâncias química caracterizadas por ressonância magnética nuclear de 1H e 13C
(Universidade Tecnológica Federal do ParanáToledoBrasilAnálise InstrumentalUTFPR, 2019-06-08)
The need for safe and reliable quality control of finished products and / or raw materials is of utmost importance to the pharmaceutical industry as well as to the users of these products, ensuring the quality, safety and ...