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In vitro metabolism of copalic and kaurenoic acids in rat and human liver microsomes
(2021-01-01)
Copalic (CA) and kaurenoic (KA) acids are the main diterpenes found in the oleoresin extracted from the copaiba tree (Copaifera sp). This study aimed to characterize the metabolism of CA and KA in rat and human liver ...
Evaluation of ent-Kaurenoic Acid Derivatives for their Anticariogenic Activity
(NATURAL PRODUCTS INC, 2011)
Ent-kaur-16(17)-en-19-oic acid (kaurenoic acid, KA) is a tetracyclic diterpene prototype for natural anticaries agents. Six KA derivatives were prepared and their antimicrobial activity against the main microorganisms ...
Effect of diterpenoid kaurenoic acid on genotoxicity and cell cycle progression in gastric cancer cell lines
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
The goal of our study was to evaluate the effect of kaurenoic acid, obtained from copaiba oil resin, in gastric cancer (GC) and a normal mucosa of stomach (MNP01) cell lines. The compound was tested at concentrations of ...
Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells
(2019-05-10)
Ethnopharmacological relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no ...
Determinação do perfil farmacocinético e da biodisponibilidade sistêmica do ácido caurenoico em ratos
(Universidade Federal de Juiz de Fora (UFJF)BrasilFaculdade de FarmáciaPrograma de Pós-graduação em Ciências FarmacêuticasUFJF, 2017)
Síntese e avaliação anti-tripanossoma e citotóxica de benzaldeído-tiossemicarbazonas derivadas do ácido caurenóico
(Universidade Estadual de MaringáBrasilPrograma de Pós-Graduação em QuímicaUEMMaringá, PRDepartamento de Química, 2018)