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Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway
(Springer, 2015-08)
Phenotypic modulation (PM) of vascular smooth muscle cells (VSMCs) is central to the process of intimal hyperplasia which constitutes a common pathological lesion in occlusive vascular diseases. Changes in the functional ...
Inhibition of striatal cholinergic interneuron activity by the Kv7 opener retigabine and the nonsteroidal anti-inflammatory drug diclofenac
(Pergamon-Elsevier Science Ltd, 2018-07)
Striatal cholinergic interneurons provide modulation to striatal circuits involved in voluntary motor control and goal-directed behaviors through their autonomous tonic discharge and their firing “pause” responses to novel ...
4-Chloro-3-nitro-N-butylbenzenesulfonamide acts on KV3.1 channels by an open-channel blocker mechanism
(2017-11-01)
The effects of 4-chloro-3-nitro-N-butylbenzenesulfonamide (SMD2) on KV3.1 channels, heterologous expressed in L-929 cells, were studied with the whole cell patch-clamp technique. SMD2 blocks KV3.1 in a reversible and ...
Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies
(OXFORD UNIV PRESS, 2009)
Genomic imprinting alterations have been shown to be associated with assisted reproductive technologies (ARTs) in animals. At present, data obtained in humans are inconclusive; however, some epidemiological studies have ...
Análisis de impactos socio-ambientales para el diseño y construcción de líneas de transmisión eléctrica de 69 kv, 138 kv y 230 kv.
(Ecuador, Latacunga: Universidad Técnica de Cotopaxi UTC., 2021)
Crotamine Pharmacology Revisited: Novel Insights Based on the Inhibition of K-V Channels
(AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICSBETHESDA, 2012)
Crotamine, a 5-kDa peptide, possesses a unique biological versatility. Not only has its cell-penetrating activity become of clinical interest but, moreover, its potential selective antitumor activity is of great pharmacological ...
Modelado de compensadores automáticos de potencia reactiva en lenguaje de programación dpl y dsl para la interconexión Ecuador-Perú 500 kv.
(Ecuador: Latacunga: Universidad Técnica de Cotopaxi (UTC), 2023)
Diseño eléctrico de la subestación El Bosque de 20/24 MVA a 69 KV con 4 circuitos de salida de 13,8 KV en la ciudad de Machala
(2013-04)
This project presents the design electrical of the substation El Bosque. The capacity of the substation is determined by the projection of the demand to long term of the electric system of the CNEL El Oro. Is established ...
Purification and characterization of Ts15, the first member of a new alpha-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Voltage-gated potassium channel toxins (KTxs) are basic short chain peptides comprising 23-43 amino acid residues that can be cross-linked by 3 or 4 disulfide bridges. KTxs are classified into four large families: alpha-, ...