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Gating of two-pore domain K+ channels by extracellular pH
(Portland Press on behalf of The Biochemical Society, 2008)
Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat
(2004)
The distribution of two-pore-domain (2P-domain) K+ channels of the TREK subfamily was studied using immunocytochemistry in the peripheral vestibular system of mouse and rat. Using RT-PCR, the mRNA for TREK-1, but not for ...
Benzenesulfonamides act as open-channel blockers on K V 3.1 potassium channel
(2019-02-07)
K V 3.1 blockers can serve as modulators of the rate of action potential firing in neurons with high rates of firing such as those of the auditory system. We studied the effects of several bioisosteres of N-alkylbenzenes ...
Rational design and synthesis of selective blockers of the K2P channel TASK-3.
(2015)
K+ channels allow the selective transfer of K+ ions inside or outside of the cell. Within this
family we find K2P channels, with four transmembrane segments and two pore domains
per subunit to form a functional dimer. These ...
Ca2+-dependent K+ channels from rat olfactory cilia characterized in planar lipid bilayers
(ELSEVIER SCIENCE BV, 2005-03-14)
Olfactory cilia contain cyclic nucleotide-gated and Ca2+-dependent Cl- conductances that underlie excitatory chemotransduction, and a Ca2+-dependent K+ (K-Ca) conductance, apparently involved in inhibitory transduction. ...
Exploring the intracellular pH-sensing mechanism of TASK-2 K2P channel
(2017)
Two-pore domain potassium (K2P) channels are responsible for maintaining the background conductance essential
to the resting membrane potential. K2P channels assemble as dimers containing two pore-forming domains and ...