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Protection of radiation-induced damage to the hematopoietic system, small intestine and salivary glands in rats by JNJ7777120 Compound, a histamine H4 ligand
(Public Library of Science, 2013-07-26)
Based on previous data on the histamine radioprotective effect on highly radiosensitive tissues, in the present work we aimed at investigating the radioprotective potential of the H4R ligand, JNJ7777120, on ionizing ...
Pharmacological targeting of histamine H4 receptor in periodontal disease
(Wiley Blackwell Publishing, Inc, 2016-02)
Objective: The objective of this study was to investigate whether histamine H4 receptor (H4R) antagonists could prevent experimental periodontitis (EP)-induced histological, functional and inflammatory alterations in ...
Efectos de JNJ7777120 sobre los canales de sodio rNav1.4 expresados en ovocitos de la rana Xenopus laevis
(Benemérita Universidad Autónoma de Puebla, 2017-06)
"El fármaco JNJ7777120 es un antihistamínico específico para el receptor de histamina H4. Debido a su potente efecto antiinflamatorio, se ha propuesto el uso de este fármaco para el tratamiento de enfermedades inflamatorias. ...
Estudio citogenético del efecto radioprotector de la Histamina y el compuesto JNJ7777120
(Universidad de Belgrano. Facultad de Ciencias Exactas y Naturales. Licenciatura en Ciencias Biológicas, 2013)
Entre los tratamientos antitumorales más importantes se encuentra la radioterapia, que por no ser
selectivo surge la necesidad de buscar agentes, llamados radioprotectores. que disminuyan la toxicidad,
la mutagenicidad ...
Pharmacological targeting of histamine H4 receptor in periodontal disease
(John Wiley & Sons, 2022)
Histamine H4 receptor agonists induce epithelial-mesenchymal transition events and enhance mammosphere formation via Src and TGF-β signaling in breast cancer cells
(Pergamon-Elsevier Science Ltd, 2020-10)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer ...
Study of the antitumour effects and the modulation of immune response by histamine in breast cancer
(Nature Publishing Group, 2020-02)
Background: The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast ...
Antitumor role of histamine h4 receptor in human t-cell lymphoma: therapeutic benefit for combination therapy with histamine and histone deacetylase inhibitors
(Fundación Revista Medicina, 2019)
The discovery of the human histamine H4 receptor (H4R) has contributed to our understanding of histamine role in numerous physiological and pathological conditions, including tumor development and progression. High histamine ...
Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model
(Wiley Blackwell Publishing, Inc, 2015-09)
Objectives: Searching for more effective and selective therapies for head and neck cancer, we demonstrated the therapeutic effect of boron neutron capture therapy (BNCT) to treat oral cancer and inhibit long-term tumor ...