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Combining Experimental Evidence and Molecular Dynamic Simulations To Understand the Mechanism of Action of the Antimicrobial Octapeptide Jelleine-I
(Amer Chemical Soc, 2014-07-29)
Jelleines are four naturally occurring peptides that comprise approximately eight or nine C-terminal residues in the sequence of the major royal jelly protein 1 precursor (Apis mellifera). The difference between these ...
Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)
(Elsevier B.V., 2004-06-01)
Four antimicrobial peptides were purified from Royal Jelly of honeybees, by using reverse phase-HPLC and sequenced by using Q-Tof-MS/MS: PFKLSLHL-NH2 (Jelleine-I), TPFKLSLHL-NH2 (Jelleine-II), EPFKLSLHL-NH2 (Jelleine-III), ...
Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera)
(Elsevier B.V., 2004-06-01)
Four antimicrobial peptides were purified from Royal Jelly of honeybees, by using reverse phase-HPLC and sequenced by using Q-Tof-MS/MS: PFKLSLHL-NH2 (Jelleine-I), TPFKLSLHL-NH2 (Jelleine-II), EPFKLSLHL-NH2 (Jelleine-III), ...
Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation
(2020-05-01)
Increasing resistance in antibiotic and chemotherapeutic treatments has been pushing studies of design and evaluation of bioactive peptides. Designing relies on different approaches from minimalist sequences and endogenous ...
Interações de peptídeos de cadeias curtas e bicamadas lipídicas: estudo biofísico e reflexos sobre a atividade biológica
(Universidade Estadual Paulista (Unesp), 2018-11-26)
O uso de peptídeos bioativos em antibioticoterapia tem dentre suas vantagens principais a reduzida possibilidade de desenvolvimento de resistência, uma vez que o alvo são os fosfolipídios constituintes da membrana celular. ...
Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity
(2019-07-08)
Antimicrobial peptides appear among innovative biopolymers with potential therapeutic interest. Nevertheless, issues concerning efficiency, production costs, and toxicity persist. Herein, we show that conjugation of peptides ...
Estudo das interações de peptídeos antimicrobianos e sistemas miméticos de membrana por dinâmica molecular
(Universidade Estadual Paulista (Unesp), 2014-08-29)
Many peptides extracted from plants and animal secretions exhibit a broad spectrum of antimicrobial activity against bacteria gram-negative, gram-positive, fungi and parasites. Due this characteristic and the increasing ...