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Estudo da via jak2/stat3 e de seus inibidores em linfomas multicêntricos difusos de grandes células B caninos
(Universidade Estadual Paulista (Unesp), 2016-11-18)
A via Janus Kinase (JAK) e do transdutor de sinal e ativador de transcrição (STAT) desempenham papéis importantes na patogênese de neoplasias hematopoiéticas. A ativação da via JAK2/STAT3 promove o crescimento e sobrevivência ...
JAK1/2 Inhibitors AZD1480 and CYT387 Inhibit Canine B-Cell Lymphoma Growth by Increasing Apoptosis and Disrupting Cell Proliferation
(Wiley-Blackwell, 2017-11-01)
Background: Canine diffuse large B-cell lymphoma (DLBCL) is a common and aggressive hematologic malignancy. The lack of conventional therapies with sustainable efficacy warrants further investigation of novel therapeutics. ...
Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage
(Nature Publishing GroupLondonInglaterra, 2009)
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children.
(IPNA2016 by Springer, 2016)
BACKGROUND:
Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation ...
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children
(Springer, 2016)
Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation of Janus ...
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children.
(IPNA2016 by Springer, 2016)
BACKGROUND:
Chronic kidney disease (CKD) in children is characterized by severe growth failure. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis in uremic animals shows a post-receptor impaired phosphorylation ...
Growth hormone signaling in fibroblasts from newborn boys and prepubertal boys
(Elsevier, 2016-04)
Background/aim: Responsiveness to GH in target cells is mediated by its receptor, which activates the Janus kinase-2 (JAK2) and STAT5 (signal transducers and activators of transcription 5) leading to the expression of IGF-1 ...