The chemopreventive and anticancer effects of resveratrol (RSV) are widely reported in the literature. Specifically, mechanisms involving epigenetic regulation are promising targets to regulate tumor development. Bromodomains ...

A protocol is developed to allow the accurate characterization of partition to lipid bilayers for solutes with low affinity, using isothermal titration calorimetry. The methodology proposed is suitable for studies using ...

Trypsin is a protease widely used in several industrial areas for leather and meat softening and to produce enzymatic detergents, among others applications. The high demand for this enzyme has motivated the development of ...

Growing ruzigrass (Urochloa ruziziensis) in crop rotation systems has been suggested as a strategy to increase soil phosphorus (P) cycling and P availability. However, despite increased P lability shown in routine soil ...

Suramin is a polysulphonated napthylurea used as an antiprotozoal/anthelminitic drug, which also inhibits a broad range of enzymes. Suramin binding to recombinant human secreted group IIA phospholipase A(2) (hsPLA(2)GIIA) ...

PEGylated proteins are an increasing important class of therapeutic drugs due to their improved pharmacokinetic characteristics and solubility over their corresponding native forms. PEGylation is the covalent attachment ...