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β-ionone inhibits nonalcoholic fatty liver disease and its association with hepatocarcinogenesis in male Wistar rats

Universidade de São Paulo (USP); Universidade Estadual Paulista (Unesp) (2019-08-01)

Among the primary neoplasias that affect the liver, hepatocellular carcinoma (HCC) is the most frequent and the third leading cause of death related to cancer. Several risk factors predispose individuals to HCC such as ...

Chemopreventive effects of beta-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA

CARDOZO, Monica Testoni; CONTI, Aline de; ONG, Thomas Prates; SCOLASTICI, Clarissa; PURGATTO, Eduardo; HORST, Maria Aderuza; BASSOLI, Bruna Kempfer; MORENO, Fernando Salvador (ELSEVIER SCIENCE INC, 2011)

Chemopreventive activities of the dietary isoprenoids beta-ionone (beta I) and geraniol (GOH) were evaluated during the promotion phase of hepatocarcinogenesis. Over 5 consecutive weeks, rats received daily 16 mg/100 g ...